BBS3 Activators
BBS3, also known as ADP-ribosylation factor-like protein 6 (ARL6), is a significant gene implicated in the biological process of intracellular trafficking and ciliary function. The protein encoded by BBS3 is a member of the small GTPase superfamily and the ARF family, which are known to be involved in a variety of cellular processes including the regulation of cytoskeletal dynamics, vesicular trafficking, and lipid droplet dynamics. BBS3 has been specifically associated with the biogenesis and proper function of primary cilia, which are sensory organelles playing a pivotal role in signal transduction pathways. The expression levels of BBS3 are crucial, as it is a part of the BBSome complex, a group of proteins that are essential for cilia function. Alterations in the expression of BBS3 can have significant effects on cellular homeostasis and intracellular communication.
Research into the molecular regulation of BBS3 has unveiled a variety of chemical compounds that can potentially induce the expression of this protein. Compounds like retinoic acid, for example, are observed to upregulate BBS3 by binding to nuclear receptors and initiating transcriptional activation of genes that are crucial for intracellular transport mechanisms. Similarly, forskolin has been shown to enhance BBS3 expression by elevating intracellular cAMP levels, thereby activating protein kinase A (PKA) and subsequent transcriptional events. Lithium, a well-documented agent in cellular models, can upregulate BBS3 expression through the inhibition of GSK-3, promoting the stabilization of β-catenin and its accumulation in the nucleus, which in turn can stimulate the transcription of GTPase-encoding genes. Epigenetic modifiers such as trichostatin A and valproic acid also play a role in modulating BBS3 levels by altering chromatin structure, thus promoting a transcriptionally active chromatin state that facilitates gene expression. These insights into the molecular dynamics of BBS3 expression provide a foundational understanding of the regulation of this gene at the cellular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may upregulate BBS3 expression by activating retinoic acid receptors that bind to retinoic acid response elements in gene promoters, stimulating transcription of genes involved in intracellular transport. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin could stimulate BBS3 expression via elevation of cAMP, which activates PKA, leading to the phosphorylation of transcription factors that drive the transcription of GTPase-encoding genes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can upregulate gene expression by inhibiting GSK-3, leading to the stabilization of β-catenin, which translocates to the nucleus and stimulates the expression of genes including those coding for GTPases. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may increase BBS3 gene transcription by inhibiting histone deacetylases, resulting in a more relaxed chromatin state that allows transcription machinery better access to the BBS3 gene promoter. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin could induce the upregulation of BBS3 by inhibiting mTOR, which may activate compensatory mechanisms that upregulate cellular traffic proteins to maintain homeostasis. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid may stimulate BBS3 expression by inhibiting histone deacetylases, causing hyperacetylation of histones, and promoting a transcriptionally active chromatin environment around BBS3 gene loci. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could induce expression of BBS3 by inhibiting DNA methyltransferases, leading to reduced methylation of the BBS3 promoter, which is often associated with increased gene expression. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $178.00 $367.00 | 7 | |
β-Catenin can upregulate BBS3 expression by translocating into the nucleus upon Wnt pathway activation and stimulating transcription factors that increase GTPase gene transcription. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone may stimulate BBS3 transcription by activating PPARγ, which binds to PPAR response elements in promoters of certain genes, leading to increased transcription of those involved in trafficking. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin could upregulate BBS3 by activating AMPK, which can induce a cascade of events leading to enhanced transcription of genes associated with cellular energy management and possibly GTPases. | ||||||