BAZ1A Inhibitors
Chemical inhibitors of BAZ1A include a variety of compounds that disrupt its role in chromatin remodeling. Trichostatin A and Scriptaid, both histone deacetylase inhibitors, increase the acetylation of histones, thereby creating a more open chromatin structure. This heightened acetylation state can interfere with BAZ1A's ability to access and modify chromatin, effectively inhibiting its function. Similarly, Entinostat's selective inhibition of histone deacetylases leads to hyperacetylation of histones, which reduces the requirement for chromatin remodeling activities of BAZ1A. Chloroquine, by intercalating into DNA, disrupts the interaction of DNA with DNA-binding proteins, including BAZ1A, impeding its chromatin remodeling capabilities. Mithramycin A competes with BAZ1A for binding to G-C rich regions of DNA, which can inhibit its function. Genistein, by inhibiting tyrosine kinases, can decrease BAZ1A's chromatin remodeling functionality if it is dependent on tyrosine phosphorylation.
Further inhibiting BAZ1A's chromatin remodeling function, Bisphenol A disrupts epigenetic marks by altering DNA methylation patterns, which affects BAZ1A's interaction with chromatin. RG108 and Decitabine, both inhibitors of DNA methyltransferases, prevent or reverse DNA methylation, thereby altering the methylation landscape that BAZ1A relies on for chromatin remodeling. BIX-01294 inhibits G9a histone methyltransferase, affecting histone methylation and thus indirectly inhibiting BAZ1A's remodeling activity. Disulfiram can impede BAZ1A by affecting protein acetylation through its interaction with copper ions, potentially inhibiting necessary post-translational modifications of BAZ1A or its associated factors. Lastly, Parthenolide inhibits the NF-κB pathway, which is crucial for the expression of genes related to chromatin structure and remodeling; by inhibiting this pathway, BAZ1A's function can be indirectly inhibited due to its reliance on the proper functioning of NF-κB-mediated processes for its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can increase the acetylation of histones, leading to a more open chromatin structure. Since BAZ1A is involved in chromatin remodeling, the heightened acetylation state can inhibit the ability of BAZ1A to access chromatin and perform its function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to intercalate into DNA, which can disrupt the interaction of DNA with DNA-binding proteins. BAZ1A, functioning in chromatin remodeling by interacting with DNA, can be functionally inhibited by chloroquine's DNA intercalation, impeding its ability to bind and remodel chromatin. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to G-C rich regions of DNA, potentially blocking the binding sites of chromatin remodeling factors, including BAZ1A. By competing for these binding sites, it can inhibit the function of BAZ1A in altering chromatin structure. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A can disrupt epigenetic marks by altering DNA methylation patterns. As BAZ1A interacts with chromatin structures influenced by methylation status, bisphenol A can indirectly inhibit BAZ1A's role in chromatin remodeling. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that can act as a tyrosine kinase inhibitor. If BAZ1A function is contingent upon tyrosine phosphorylation, genistein's inhibition of this process can decrease BAZ1A's functionality in chromatin remodeling. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor that prevents DNA methylation. BAZ1A is implicated in chromatin remodeling, which can be influenced by DNA methylation patterns. Thus, RG108 can inhibit BAZ1A's ability to interact with chromatin by altering its methylation landscape. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
Scriptaid is another histone deacetylase inhibitor, which, similarly to Trichostatin A, can lead to increased histone acetylation and chromatin relaxation. This state can inhibit BAZ1A's activity by reducing its chromatin binding and remodeling capabilities. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is an inhibitor of G9a histone methyltransferase, which methylates histone H3 at lysine 9. Since BAZ1A functions in chromatin remodeling and can be influenced by histone methylation, the inhibition of G9a by BIX-01294 can indirectly inhibit the function of BAZ1A. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is an inhibitor of DNA methyltransferases, causing hypomethylation of DNA. This alteration in the methylation state of DNA can affect the ability of BAZ1A to remodel chromatin, thereby functionally inhibiting it. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat is a selective histone deacetylase inhibitor that can lead to hyperacetylation of histones and thus a more relaxed chromatin conformation. As a chromatin remodeler, BAZ1A's function can be inhibited by entinostat due to the decreased necessity for chromatin remodeling in a hyperacetylated environment. | ||||||