BAT5 Inhibitors
BAT5 Inhibitors are a class of chemical compounds that act by interfering with the biological processes and signaling pathways in which the BAT5 protein is involved. This includes vital cellular processes such as purine metabolism, RNA metabolism, and DNA synthesis and repair. For instance, Azathioprine, Methotrexate, Hydroxyurea, and Cladribine are compounds that disrupt purine synthesis and DNA synthesis, indirectly inhibiting BAT5 activity. Azathioprine's immunosuppressive action inhibits purine synthesis, while Methotrexate's inhibition of dihydrofolate reductase and Hydroxyurea's inhibition of ribonucleotide reductase both disrupt DNA synthesis. Cladribine, a purine analogue, disrupts DNA synthesis and repair by incorporating into DNA.
Furthermore, compounds such as 5-Azacytidine, Dactinomycin, and Valproic acid target RNA metabolism, which is another pathway in which BAT5 is involved. 5-Azacytidine incorporates into DNA and RNA, inhibiting DNA methyltransferases and altering gene expression, while Dactinomycin intercalates into DNA, inhibiting RNA synthesis. Valproic acid, a histone deacetylase inhibitor, influences gene expression, which could indirectly inhibit BAT5 activity. Finally, compounds that disrupt DNA structures and DNA repair, such as Etoposide, Cisplatin and Bleomycin, could also indirectly inhibit BAT5 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
Azathioprine is an immunosuppressive drug that inhibits purine synthesis. BAT5 is involved in the urea cycle and purine metabolism, and azathioprine's inhibition of purine synthesis could indirectly decrease BAT5 activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is a folic acid analogue that inhibits dihydrofolate reductase, affecting DNA synthesis and repair. As BAT5 is involved in purine metabolism, which is crucial for DNA synthesis, methotrexate could indirectly inhibit BAT5 activity. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, disrupting DNA synthesis. Given that BAT5 is involved in purine metabolism necessary for DNA synthesis, it can indirectly inhibit BAT5 activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine incorporates into DNA and RNA, inhibiting DNA methyltransferases and altering gene expression. As BAT5 is involved in RNA metabolism, 5-Azacytidine could indirectly inhibit BAT5 activity. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is a pyrimidine analogue that inhibits thymidylate synthase, disrupting DNA synthesis. As BAT5 plays a role in purine metabolism, which is necessary for DNA synthesis, it could indirectly inhibit BAT5 activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Dactinomycin intercalates into DNA, inhibiting RNA synthesis. Since BAT5 is involved in RNA metabolism, dactinomycin's inhibition of RNA synthesis could indirectly inhibit BAT5 activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits topoisomerase II, causing DNA strand breaks. Given that BAT5 is involved in DNA repair, etoposide could indirectly inhibit BAT5 activity. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms intrastrand and interstrand DNA crosslinks, disrupting DNA replication and transcription. Since BAT5 is involved in DNA repair, cisplatin's disruption of DNA structures could indirectly inhibit BAT5 activity. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $210.00 $624.00 $1040.00 $2913.00 | 38 | |
Bleomycin causes DNA strand breaks. BAT5, involved in DNA repair, could have its activity indirectly inhibited by bleomycin. | ||||||
Acyclovir | 59277-89-3 | sc-202906 sc-202906A | 50 mg 500 mg | $150.00 $940.00 | 2 | |
Acyclovir is a guanosine analogue that inhibits viral DNA polymerase, disrupting DNA synthesis. As BAT5 is involved in purine metabolism necessary for DNA synthesis, acyclovir could indirectly inhibit BAT5 activity. | ||||||