BAF60a Inhibitors
BAF60a inhibitors are chemical compounds that specifically target and inhibit the activity of BAF60a, a subunit of the SWI/SNF chromatin remodeling complex. The SWI/SNF complex plays a crucial role in modulating chromatin structure, which allows access to DNA for transcription, replication, and repair processes. BAF60a is one of the variants of the BAF60 subunit family, and it is involved in bridging the interactions between transcription factors and the chromatin remodeling machinery. By interacting with specific transcription factors, BAF60a influences the recruitment of the SWI/SNF complex to particular genomic loci, affecting gene expression patterns and cellular function. BAF60a plays an important role in regulating genes involved in developmental and metabolic processes, making it a key component in chromatin dynamics.
Inhibitors of BAF60a function by blocking its interaction with transcription factors or other components of the SWI/SNF complex, thereby disrupting the chromatin remodeling process. By inhibiting BAF60a, these compounds alter the accessibility of specific regions of the genome to the transcriptional machinery, potentially affecting the expression of a wide range of genes. This inhibition can have downstream effects on various cellular processes dependent on precise transcriptional regulation, such as differentiation and metabolic control. BAF60a inhibitors are valuable research tools for exploring the complex roles that chromatin remodeling plays in gene expression and cellular dynamics. They allow scientists to investigate the specific contributions of BAF60a to SWI/SNF complex function and its broader impact on chromatin architecture and cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor, could modulate gene expression and chromatin dynamics affecting BAF60a. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
A potent histone deacetylase inhibitor, might alter chromatin accessibility, indirectly influencing BAF60a. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
A histone deacetylase inhibitor, known to affect chromatin structure and gene expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Similar to 5-Azacytidine, impacts DNA methylation and could indirectly influence BAF60a. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
A BET bromodomain inhibitor, affects transcriptional regulation, potentially impacting BAF60a-related pathways. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
Another BET bromodomain inhibitor, could modulate transcriptional activities involving BAF60a. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A DNA methyltransferase inhibitor, might alter gene expression profiles relevant to BAF60a function. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
A selective EZH2 methyltransferase inhibitor, potentially affecting chromatin states impacting BAF60a. | ||||||
Nexturastat A | 1403783-31-2 | sc-478176 | 1 mg | $330.00 | ||
A BET bromodomain inhibitor, could influence transcriptional regulation and chromatin remodeling affecting BAF60a. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
A histone acetyltransferase inhibitor, might indirectly influence chromatin dynamics and BAF60a function. | ||||||