B-Myc Activators
B-Myc Activators encompass a diverse set of chemical compounds that operate through various biochemical mechanisms to enhance the activity of B-Myc. Forskolin, through its action on adenylate cyclase, raises intracellular cAMP levels, leading to the activation of PKA, which may phosphorylate B-Myc and thus augment its role in signal transduction processes. Similarly, dibutyryl-cAMP, a stable cAMP analog, activates PKA, potentially leading to enhanced phosphorylation and activity of B-Myc. Retinoic acid and sodium butyrate, by modulating retinoid signaling and histone acetylation respectively, are believed to influence the transcriptional regulation of B-Myc, thereby enhancing its cellular function. Epigallocatechin gallate indirectly increases B-Myc activity by inhibiting kinases that would otherwise negatively regulate it, and Trichostatin A, by inhibiting histone deacetylases, may also elevate B-Myc activity by allowing for a more transcriptionally active chromatin state around the MYCBP gene.
Additional compounds, such as Phorbol 12-myristate 13-acetate (PMA) and sphingosine-1-phosphate, enhance B-Myc activity through the activation of PKC and sphingosine kinase signaling pathways, respectively, which can lead to post-translational modifications of B-Myc that increase its functionality. LY294002 and rapamycin, by inhibiting PI3K and mTOR respectively, might modulate downstream signaling cascades in a manner that allows B-Myc to play a more prominent role in cellular growth.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase leading to an increase in cAMP levels. Elevated cAMP activates PKA, which can phosphorylate B-Myc, enhancing its activity in cellular signaling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates retinoid signaling pathways, which can upregulate B-Myc activity through transcriptional regulation and post-translational modifications. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This catechin inhibits kinases that negatively regulate B-Myc, thus enhancing B-Myc activity indirectly by reducing inhibitory phosphorylations. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs), which can result in a more relaxed chromatin structure around the MYCBP gene, potentially enhancing B-Myc expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator that can enhance B-Myc activity by promoting phosphorylation events that increase its functional activity in signal transduction. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate activates sphingosine kinase, influencing signaling pathways that could lead to the post-translational modification of B-Myc, enhancing its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, activates PKA, which subsequently could phosphorylate B-Myc, thereby enhancing its role in cellular processes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is an HDAC inhibitor that can lead to hyperacetylation of histones near the MYCBP gene, potentially enhancing B-Myc activity through increased gene expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, which can alter downstream signaling pathways leading to modifications in B-Myc activity by altering the cellular context in which B-Myc operates. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which can shift cellular signaling in a manner that may upregulate B-Myc activity through indirect effects on cellular growth and metabolism. | ||||||