AW209491 Inhibitors
Chemical inhibitors of AW209491 can impact its activity through various mechanisms depending on the signaling pathways the protein is involved in. Staurosporine, a potent protein kinase inhibitor, non-selectively targets protein kinases, which are crucial for phosphorylation processes within the cell. By inhibiting these kinases, staurosporine can prevent the phosphorylation that is essential for the activation of AW209491. Similarly, Bisindolylmaleimide I specifically targets protein kinase C (PKC), and inhibition by this chemical would lead to a decrease in AW209491 activity if PKC-mediated phosphorylation is necessary for its function.
Imatinib functions by selectively inhibiting certain tyrosine kinases that are known to be upstream of AW209491, thus blocking the necessary signaling events for AW209491 activation. In a parallel mechanism, Gefitinib inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase, which could also lead to a decrease in AW209491 activity if EGFR signaling is required for its function. LY294002 and Wortmannin both target phosphoinositide 3-kinases (PI3K), which play a pivotal role in the PI3K/Akt pathway. The inhibition of this pathway would result in reduced activity of AW209491 if it is a downstream effector. Triciribine operates by inhibiting Akt itself, further supporting the inhibition of AW209491 if it is activated by Akt-mediated signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine non-selectively inhibits protein kinases which could be involved in the phosphorylation of AW209491, thus inhibiting its activity by preventing essential phosphorylation events. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib selectively inhibits certain tyrosine kinases that are upstream of AW209491 in signaling pathways, leading to functional inhibition of AW209491 by blocking signaling events required for its activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits phosphoinositide 3-kinases (PI3K), potentially reducing the activity of AW209491 if it operates downstream of the PI3K/Akt pathway by preventing the production of PIP3, a critical second messenger in this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, which could lead to the inhibition of AW209491 by blocking the PI3K/Akt pathway and subsequent downstream signaling processes that activate AW209491. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, leading to the inhibition of the ERK pathway. AW209491, if it functions downstream of the ERK pathway, would be inhibited due to the suppression of MEK activity and subsequent ERK signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK, and thereby inhibits the ERK pathway. AW209491 activity would be inhibited due to the lack of ERK pathway signaling, assuming its activity is contingent upon this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAP kinase, which could lead to the functional inhibition of AW209491 by blocking the signaling pathways that require p38 MAPK activity, if AW209491 is a downstream effector in these pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits the JNK pathway, potentially inhibiting AW209491 by halting downstream signaling processes that depend on JNK activity, thus preventing AW209491 from being functionally active. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I specifically inhibits PKC, which could lead to the inhibition of AW209491 if it is involved in PKC-dependent signaling pathways, by preventing PKC-mediated signaling required for AW209491 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which could inhibit AW209491 by preventing the activation of downstream signaling pathways that require mTOR activity, and in which AW209491 is involved. | ||||||