AW209491 Activators
AW209491 activators are a curated selection of chemical entities that enhance the protein's activity through targeted actions on specific signaling pathways. The activators orchestrate a coordinated elevation of AW209491 activity by modulating the cellular signaling landscape. For instance, Forskolin and 8-Bromo-cAMP elevate cAMP levels, leading to PKA activation, which in turn phosphorylates proteins within AW209491's regulatory network, thus enhancing its activity. Similarly, Epigallocatechin gallate (EGCG) inhibits certain kinases that would otherwise suppress AW209491 activity, thereby allowing for an increase in its functional role. Phorbol 12-myristate 13-acetate (PMA) and Sphingosine-1-phosphate operate through PKC activation and sphingolipid signaling, respectively, each triggering signaling cascades that culminate in the augmentation of AW209491 activity, demonstrating the intricate interplay between lipid signaling and protein activation.
Complementing these are compounds like Ionomycin and A23187, both of which modulate intracellular calcium levels, a second messenger crucial for numerous signaling pathways that could intersect with those regulated by AW209491. The PI3K inhibitors, LY294002 and Wortmannin, relieve AW209491 from PI3K/AKT pathway-mediated inhibition, promoting its functional activity. Additionally, the MEK inhibitor U0126 and the p38 MAPK inhibitor SB203580 selectively inhibit components of the MAPK pathway, potentially diverting signaling to AW209491-engaged pathways, and thereby enhancing its activity. This diverse arsenal of AW209491 activators underscores the complexity of signaling networks and provides a means to selectively augment AW209491 activity through a spectrum of biochemical interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene that activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate a variety of substrates, including proteins potentially regulated by AW209491, thereby enhancing AW209491 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol found in green tea with kinase inhibition properties. By inhibiting certain kinases, EGCG could reduce the negative regulatory influences on pathways that AW209491 is involved in, thus potentially enhancing the activity of AW209491. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diester of phorbol and functions as a potent activator of protein kinase C (PKC). PKC activation can lead to phosphorylation of proteins that may interact with AW209491 or are part of the same signaling cascade, enhancing the activity of AW209491. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. This activation can enhance the activity of AW209491 if it is calcium-dependent or interacts with calcium-regulated proteins. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a signaling lipid that activates sphingosine-1-phosphate receptors, leading to the activation of downstream signaling pathways that could intersect with those regulated by AW209491, enhancing its activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to the phosphorylation of proteins in pathways involving AW209491, thus enhancing the activity of AW209491. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels, potentially enhancing AW209491 activity through calcium-dependent pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, which can alter the AKT signaling pathway. If AW209491's activity is regulated negatively by PI3K/AKT pathway, inhibition by LY294002 could enhance the activity of AW209491. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, similar in function to LY294002, and can enhance the activity of AW209491 through the same mechanism as described above. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. By inhibiting this pathway, U0126 could shift the balance of cellular signaling to favor pathways in which AW209491 is active, thereby enhancing its activity. | ||||||