AV320801 Activators
Chemical activators of PRAME like 3E can modulate the protein's activity through different intracellular signaling pathways. Phorbol 12-myristate 13-acetate (PMA) directly stimulates protein kinase C (PKC), which is known for its role in phosphorylating various target proteins, including PRAME like 3E. This phosphorylation can alter PRAME like 3E's activity, thereby modulating its function in cellular processes. Similarly, Forskolin raises intracellular cAMP levels by activating adenylyl cyclase. Elevated cAMP activates protein kinase A (PKA), another kinase that can phosphorylate PRAME like 3E, leading to changes in its activity. Ionomycin, by increasing intracellular calcium levels, can initiate calcium-dependent signaling cascades that involve the activation of kinases capable of phosphorylating PRAME like 3E. Dibutyryl-cAMP, a cAMP analog, also activates PKA and can result in the phosphorylation of PRAME like 3E, affecting its function.
Other activators like Epidermal Growth Factor (EGF) interact with their respective receptors to kick-start signal transduction pathways involving multiple kinases, with the potential of phosphorylating PRAME like 3E as part of the cellular signaling network. Retinoic acid, by binding to its receptors, can influence gene expression and cellular differentiation, leading to changes in phosphorylation patterns of proteins, including PRAME like 3E. Bradykinin and Histamine bind their respective receptors and can activate phospholipase C, resulting in the production of diacylglycerol (DAG) and inositol triphosphate (IP3), secondary messengers that lead to PKC activation, which can then target PRAME like 3E. Calmodulin, upon binding calcium, activates various kinases and phosphatases, which may phosphorylate PRAME like 3E. Thapsigargin disrupts calcium homeostasis by inhibiting the SERCA pump, which can lead to the activation of calcium-dependent proteins that may target PRAME like 3E. Lastly, hydrogen peroxide, as a reactive molecule, can activate signaling pathways that involve kinases capable of modifying PRAME like 3E, while Isoproterenol, a beta-adrenergic agonist, increases cAMP, which in turn activates PKA, possibly resulting in the phosphorylation of PRAME like 3E.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can then phosphorylate PRAME like 3E, leading to its functional activation in the cell. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as an ionophore for calcium, raising intracellular calcium levels, which can activate calcium-dependent signaling pathways, potentially leading to the phosphorylation and activation of PRAME like 3E. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid binds to retinoic acid receptors, which can alter gene expression and cellular differentiation pathways that include the activation of proteins like PRAME like 3E through altered phosphorylation patterns. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. Activated PKA can phosphorylate target proteins, which may include PRAME like 3E, leading to its activation within various signaling pathways. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin interacts with bradykinin receptors leading to the activation of phospholipase C and release of IP3 and DAG, second messengers that lead to the activation of PKC, which could then phosphorylate and activate PRAME like 3E. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds to its G-protein coupled receptors, which can stimulate phospholipase C activity, leading to a cascade that involves PKC activation. PKC may then phosphorylate PRAME like 3E, leading to its activation. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Calmodulin, upon binding calcium, becomes an active complex that can interact with and activate various kinases and phosphatases that can, in turn, phosphorylate proteins such as PRAME like 3E, leading to their activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor, which leads to increased cytosolic calcium levels and may activate calcium-dependent proteins and pathways, potentially leading to the activation of PRAME like 3E through subsequent phosphorylation events. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide is a reactive oxygen species that can act as a signaling molecule, promoting the activation of various kinases which could phosphorylate and activate PRAME like 3E as part of cellular response to oxidative stress. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can increase intracellular cAMP, leading to activation of PKA. PKA can then phosphorylate and activate proteins within the cell, potentially including PRAME like 3E in signal transduction pathways. | ||||||