AV320801 Inhibitors
Chemical inhibitors of PRAME like 3E can lead to the functional inhibition of this protein through several mechanisms, primarily by disrupting its degradation pathway. Proteasome inhibitors such as MG-132, Lactacystin, Bortezomib, Carfilzomib, Oprozomib, Marizomib, Velcade, Ixazomib, and Delanzomib, all function by impeding the proteasomal degradation process. The proteasome is a complex that degrades ubiquitinated proteins, and its inhibition results in the accumulation of such proteins within the cell. When the proteasome's activity is halted, ubiquitinated PRAME like 3E accumulates, which can lead to an overload of the protein within the cell. This accumulation can disrupt normal cellular processes, as the excess protein may aggregate or fail to fold properly, leading to functional inhibition. The accumulation of PRAME like 3E due to proteasome inhibition can also interfere with its normal turnover, which is crucial for maintaining cellular homeostasis.
Additionally, certain chemicals can influence the post-translational modification of proteins, thereby affecting their function. For instance, Exemestane and Aminoglutethimide, which are known to influence steroid synthesis and consequently the cellular environment, can alter the modification state of PRAME like 3E. Changes in the post-translational modification can affect the protein's stability, its interactions with other cellular components, or its overall activity within the cell. By altering these modifications, Exemestane and Aminoglutethimide can lead to the functional inhibition of PRAME like 3E, as the protein may not be able to participate in its normal cellular functions effectively. Benzyl isothiocyanate also engages in this process by inhibiting the ubiquitin-proteasome pathway, potentially leading to the same outcome of aggregation or misfolding due to impaired degradation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzyl isothiocyanate | 622-78-6 | sc-204641 sc-204641A | 5 g 25 g | $47.00 $156.00 | 1 | |
Benzyl isothiocyanate inhibits the ubiquitin-proteasome pathway, which is crucial for the degradation of misfolded proteins. By inhibiting this pathway, the degradation of PRAME like 3E could be hindered, leading to functional inhibition due to aggregation or misfolding. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. The accumulation of ubiquitinated PRAME like 3E could result in its functional inhibition due to the impairment of its normal degradation and turnover. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin specifically inhibits the proteasomal degradation pathway. The proteasome’s inability to degrade PRAME like 3E would result in an accumulation of the protein, potentially leading to a loss of function due to aggregation or improper folding. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a dipeptidyl boronic acid analog that inhibits the 26S proteasome. This inhibition can lead to the accumulation of PRAME like 3E, which may cause functional inhibition as a result of excess protein disrupting cellular processes. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $41.00 | ||
Carfilzomib irreversibly inhibits the 20S proteasome, leading to the buildup of polyubiquitinated proteins. This can cause the functional inhibition of PRAME like 3E by preventing its regular proteasomal degradation. | ||||||
Oprozomib | 935888-69-0 | sc-477447 | 2.5 mg | $280.00 | ||
Oprozomib is a proteasome inhibitor that can lead to the accumulation of ubiquitinated PRAME like 3E, thereby inhibiting its function due to the impairment of its normal degradation process. | ||||||
Ixazomib | 1072833-77-2 | sc-489103 sc-489103A | 10 mg 50 mg | $311.00 $719.00 | ||
Ixazomib selectively inhibits the 20S proteasome, leading to an increase in ubiquitinated PRAME like 3E, which could lead to functional inhibition due to disruption of normal protein turnover. | ||||||
Delanzomib, free base | 847499-27-8 | sc-396774 sc-396774A | 5 mg 10 mg | $160.00 $300.00 | ||
Delanzomib is a proteasome inhibitor that can lead to the accumulation of PRAME like 3E, potentially causing functional inhibition by impairing its degradation pathway. | ||||||
Exemestane | 107868-30-4 | sc-203045 sc-203045A | 25 mg 100 mg | $134.00 $411.00 | ||
Exemestane is an aromatase inhibitor that reduces estrogen levels, which can influence the post-translational modification of proteins. Specifically, it could inhibit the function of PRAME like 3E by altering its modification state, affecting its activity. | ||||||
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $42.00 $146.00 $541.00 $2060.00 | 2 | |
Aminoglutethimide inhibits the synthesis of several steroids, potentially altering the cellular environment and post-translational modifications of proteins. This could lead to the functional inhibition of PRAME like 3E by affecting its stability or interaction with other proteins. | ||||||