ATRX Activators
Common ATRX Activators include, but are not limited to 5-Azacytidine CAS 320-67-2, Hydroxyurea CAS 127-07-1, Etoposide (VP-16) CAS 33419-42-0, Cisplatin CAS 15663-27-1 and Methyl methanesulfonate CAS 66-27-3.
The ATRX gene encodes the ATRX protein, a member of the SWI/SNF family of proteins. These proteins are known for their involvement in a variety of processes within the cell, such as DNA repair, replication, and gene expression. Specifically, the ATRX protein interacts with the DNA structure, influencing its architecture and chromatin remodeling. The ATRX protein has a helicase and ATPase activity, essential for moving DNA molecules and altering the DNA's physical structure. The ATRX protein's critical role is underscored by its implication in several cellular functions, including telomere maintenance and genomic stability.
ATRX Activators are a group of chemical compounds designed to increase the activity of the ATRX protein. These activators aim to enhance the protein's ability to interact with DNA and modulate chromatin structure. By doing so, they impact various cellular processes where ATRX plays a role. The development and characterization of ATRX activators provide valuable tools for researchers to study the intricate roles of ATRX in cellular mechanisms. The design of these activators requires a profound understanding of the ATRX protein's structure and function, ensuring that these molecules can effectively enhance its activity. Furthermore, the discovery of ATRX activators can shed light on the broader implications of ATRX in genomic integrity, chromatin dynamics, and other essential cellular functions. As research progresses, the nuanced understanding of these activators' action can help elucidate the multifaceted roles of ATRX in cellular health.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can reactivate silenced genes. Given ATRX's role in chromatin, alterations in methylation might upregulate ATRX expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Induces replication stress, potentially leading to increased ATRX expression as a response to manage and repair stalled replication forks. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
DNA topoisomerase II inhibitor causing DNA double-strand breaks. Given ATRX's involvement in DNA repair, its expression might be induced. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Forms DNA adducts and cross-links, potentially inducing ATRX expression as part of the DNA damage response. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
Causes DNA alkylation damage. The resulting DNA repair processes might stimulate ATRX expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Known to influence gene expression and chromatin remodeling, it might affect ATRX expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A kinase inhibitor that affects multiple signaling pathways and can alter gene expression, potentially inducing ATRX. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
An HDAC inhibitor that affects histone acetylation and can lead to changes in gene expression, potentially inducing ATRX. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Can modulate gene expression patterns and might influence ATRX levels. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
A glycolysis inhibitor that induces cellular stress, potentially leading to ATRX upregulation. | ||||||