ATR2 Activators
ATR2 Activators are an ensemble of chemical compounds that augment the functional activity of ATR2 through several distinct molecular pathways. Resveratrol and Nicotinamide mononucleotide (NMN) both enhance the SIRT1 signaling pathway, which is closely tied to cellular stress responses and DNA repair mechanisms, thereby contributing to the activation of ATR2's role in maintaining genomic stability. Curcumin and Sulforaphane exert their effects through modulation of the NF-κB and Nrf2 pathways, respectively, both of which are essential in the cellular defense against stress and DNA damage, leading to the indirect enhancement of ATR2 activity.
Sildenafil and Quercetin act through phosphodiesterase inhibition and PI3K/Akt signaling modulation, culminating in the phosphorylation of downstream targets that are part of the cell cycle and DNA repair pathways, where ATR2 is a critical player. Additionally, compounds like Epigallocatechin gallate (EGCG) and Olaparib selectively inhibit kinases and PARP enzymes, allowing ATR2 to compensate and enhance its DNA repair activity. Caffeine, while an inhibitor of ATM and ATR kinases, may lead to a rebound effect that upregulates ATR2 function in DNA damage response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1 signaling, which can enhance the activity of ATR2 by improving cellular resistance to stress and promoting DNA repair mechanisms that ATR2 is involved in. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates the NF-κB pathway, which in turn can upregulate the cellular response to stress and DNA damage mechanisms where ATR2 plays a crucial role. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin influences PI3K/Akt signaling, which is linked to cellular survival and DNA repair processes, thereby potentially increasing the functional activity of ATR2 in response to DNA damage. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several kinases and as a result may enhance ATR2's role in the DNA damage response by reducing competitive signaling pathways that might otherwise limit ATR2's activity. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib, a PARP inhibitor, enhances DNA damage responses by preventing DNA repair, leading to increased activity of ATR2 as a compensatory mechanism in DNA damage sensing and repair. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits ATM and ATR kinases indirectly, which can paradoxically lead to a compensatory upregulation of ATR2's function in response to DNA damage and replication stress. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, which is involved in cellular energy homeostasis and can indirectly increase ATR2 activity by promoting the cellular response to metabolic stress that ATR2 monitors. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
β-Nicotinamide mononucleotide enhances NAD+ levels, which can support SIRT1 activity and thus indirectly promote ATR2's role in DNA repair and genomic stability. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium activates GSK-3β signaling, which has been implicated in DNA damage response pathways, potentially enhancing the role of ATR2 in these processes. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
Homocysteine influences methylation pathways and can modulate DNA repair mechanisms, which may lead to an increase in ATR2's functional activity in maintaining genomic integrity. | ||||||