ATP8B3 Activators
ATP8B3 activators encompass a variety of chemical compounds that enhance the functional activity of ATP8B3 by influencing specific cellular pathways or processes related to lipid metabolism, membrane dynamics, and ion transport. Phosphatidylserine and cardiolipin, as important phospholipids, play a crucial role in maintaining membrane structure and fluidity, which is essential for the optimal activity of membrane-bound proteins like ATP8B3. Lysophosphatidylcholine and sphingosine-1-phosphate modulate membrane curvature and tension, which could facilitate the function of ATP8B3 in maintaining phospholipid asymmetry.
Secondary messengers such as cAMP and signaling molecules like UTP can activate various kinases and signaling cascades that might indirectly enhance the flippase activity of ATP8B3. The modulation of intracellular calcium levels by ionophores can influence numerous calcium-dependent pathways, potentially impacting ATP8B3 activity. Bile acidsSince the protein of interest is ATP8B3 and no specific direct activators are mentioned, the following table lists chemicals that could indirectly enhance the functional activity of ATP8B3 by affecting cellular pathways or processes that ATP8B3 is likely involved in, such as lipid transport and homeostasis.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $78.00 | ||
Being a primary component of the inner leaflet of the plasma membrane, phosphatidylserine enhances membrane fluidity, potentially increasing the efficiency of ATP8B3's flippase activity which maintains phospholipid asymmetry in cell membranes. | ||||||
L-α-Lysophosphatidylcholine (from egg yolk) | 9008-30-4 | sc-473611 sc-473611A sc-473611B sc-473611C | 25 mg 100 mg 500 mg 1 g | $85.00 $235.00 $595.00 $1080.00 | 1 | |
Lysophosphatidylcholine can modulate membrane curvature and tension, potentially facilitating the translocation of phospholipids by ATP8B3 and indirectly enhancing its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
By modulating sphingolipid metabolism and signaling, sphingosine-1-phosphate could indirectly enhance ATP8B3 activity by altering membrane dynamics and composition. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
As a secondary messenger, cAMP may enhance ATP8B3 activity by activating protein kinase A (PKA), which could potentially phosphorylate and activate ATP8B3 or its associated proteins. | ||||||
Uridine-5′-triphosphate, Trisodium Salt | 19817-92-6 | sc-301964 sc-301964A | 50 mg 1 g | $86.00 $118.00 | 2 | |
UTP serves as a signaling molecule, potentially enhancing ATP8B3 activity through purinergic receptors, leading to cellular responses that could indirectly activate ATP8B3. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 increases intracellular calcium levels, which can modulate various calcium-dependent pathways, potentially upregulating ATP8B3 activity as a response to altered ionic balances. | ||||||
Chenodeoxycholic acid, free acid | 474-25-9 | sc-278835 sc-278835A | 1 g 5 g | $27.00 $115.00 | ||
Bile acids can influence ATP8B3 activity by integrating into cellular membranes and affecting membrane composition and fluidity, which could indirectly enhance the flippase activity of ATP8B3. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
As a chemical chaperone, 4-Phenylbutyrate may enhance the functional activity of ATP8B3 by aiding in proper folding and localization to the membrane, where it performs its flippase activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin alters membrane fluidity and modulates signaling pathways, which may indirectly enhance ATP8B3 activity by optimizing the membrane environment for its action. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
As a PPAR-gamma agonist, pioglitazone modulates lipid metabolism which could lead to an indirect enhancement of ATP8B3 activity by affecting the lipid composition of membranes. | ||||||