ATGL Activators
ATGL activators belong to a specialized category of chemical compounds that interact with Adipose Triglyceride Lipase (ATGL), a key enzyme involved in lipid metabolism and energy homeostasis. ATGL, also known as PNPLA2 (Patatin-Like Phospholipase Domain Containing 2), plays a central role in the hydrolysis of triglycerides stored in adipose tissue, releasing fatty acids for energy production and other metabolic processes. When activated by specific compounds, ATGL undergoes conformational changes or post-translational modifications that enhance its enzymatic activity, leading to the breakdown of triglycerides into glycerol and fatty acids.
The activation of ATGL is a crucial step in the regulation of lipid mobilization and energy balance within the body. These activators modulate the efficiency and rate of triglyceride hydrolysis, impacting the availability of fatty acids for cellular energy production and other metabolic pathways. Understanding the chemical properties and mechanisms underlying ATGL activation is essential for unraveling the complexities of lipid metabolism and its role in maintaining metabolic homeostasis. Research in this field can provide insights into the broader landscape of energy regulation, obesity, and metabolic disorders, contributing to a deeper understanding of how the body manages its energy resources and responds to changes in nutrient availability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can enhance ATGL expression through PKA-mediated signaling pathways. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
As a PPARγ agonist, rosiglitazone may upregulate ATGL expression by modulating transcription factors involved in lipid metabolism. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine increases lipolysis through the inhibition of phosphodiesterase, leading to elevated cAMP and potentially upregulating ATGL expression. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Nicotinic acid can influence lipid metabolism and may increase ATGL expression through its effects on GPR109A receptors and downstream signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a bioactive compound in turmeric, may enhance ATGL expression by modulating inflammatory pathways and affecting adipocyte differentiation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, can regulate gene expression and may induce ATGL through retinoid receptors affecting lipid metabolism. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
As a monounsaturated fatty acid, oleic acid can modulate lipid metabolism pathways, potentially influencing ATGL expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
(-)-Epigallocatechin Gallate, a major component of green tea, may enhance ATGL expression through antioxidant effects and modulation of lipid metabolic pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, found in grapes, can activate SIRT1 and AMPK pathways, potentially leading to increased ATGL expression. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
As a PPARγ agonist, similar to rosiglitazone, pioglitazone may upregulate ATGL expression by influencing lipid metabolism genes. | ||||||