ATF-5 Inhibitors
ATF-5, or activating transcription factor 5, is a transcription factor that plays a critical role in regulating gene expression in response to various cellular stressors. It belongs to the ATF/cyclic AMP-responsive element-binding (CREB) protein family and contains a basic leucine zipper (bZIP) domain, which allows it to bind to specific DNA sequences known as cAMP-responsive elements (CREs). ATF-5 is involved in diverse cellular processes, including cell proliferation, differentiation, apoptosis, and stress responses. Under normal physiological conditions, ATF-5 expression is tightly regulated, but its activity can be induced by a variety of stress signals, including oxidative stress, endoplasmic reticulum stress, and DNA damage.
Inhibition of ATF-5 function can have profound effects on cellular homeostasis and may impact cell survival and proliferation. One mechanism of inhibition involves disrupting the binding of ATF-5 to its target DNA sequences, thereby preventing the transcriptional activation of downstream target genes. This can be achieved through various means, such as small molecule inhibitors that interfere with the DNA-binding activity of ATF-5 or by targeting upstream signaling pathways that regulate ATF-5 expression or activity. Additionally, inhibition of ATF-5 may involve strategies aimed at promoting its degradation or blocking its interaction with co-factors necessary for transcriptional activation. By inhibiting ATF-5, it may be possible to modulate cellular responses to stress and mitigates pathological processes associated with ATF-5 dysregulation, such as cancer progression, neurodegenerative diseases, and metabolic disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $90.00 $326.00 | 13 | |
Radicicol is a Hsp90 inhibitor that interferes with the function of heat shock proteins, leading to destabilization and degradation of client proteins. ATF-5, as a substrate of Hsp90, can be targeted by radicicol, resulting in its degradation and inhibition. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin is a platinum-containing chemotherapeutic agent that forms DNA adducts, inducing DNA damage. The DNA damage response pathways, in turn, can modulate ATF-5 expression and activity, providing an indirect means of inhibiting ATF-5 function through disruption of its regulatory mechanisms. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A-769662 is an AMP-activated protein kinase (AMPK) activator. By activating AMPK, it can indirectly inhibit ATF-5, as AMPK activation is known to suppress the mTORC1 pathway. ATF-5 is a downstream target of mTORC1, and its activity can be modulated through this indirect mechanism. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose is a glucose analog that competitively inhibits glycolysis. ATF-5, as a transcription factor, is sensitive to changes in cellular energy metabolism. Inhibiting glycolysis with 2-deoxy-D-glucose can modulate ATF-5 activity by altering the cellular metabolic state. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin, like radicicol, is an Hsp90 inhibitor. By disrupting Hsp90 function, geldanamycin can lead to the degradation of ATF-5, as it relies on Hsp90 for stability. This represents an indirect approach to inhibit ATF-5 by targeting its protein folding and stability mechanisms. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that disrupts the degradation of ubiquitinated proteins. ATF-5, being a substrate for ubiquitination and subsequent proteasomal degradation, can accumulate in the presence of bortezomib, leading to its functional inhibition through altered protein turnover dynamics. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor. ATF-5 is a downstream target of the PI3K/Akt/mTOR pathway, and inhibition of PI3K by wortmannin can suppress this pathway, indirectly inhibiting ATF-5 function by disrupting the signaling cascade that regulates its activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is an adenosine receptor antagonist and a phosphodiesterase inhibitor. By blocking adenosine receptors, caffeine can modulate intracellular cAMP levels and affect ATF-5 activity. Additionally, its impact on phosphodiesterases may alter cellular signaling pathways, indirectly influencing ATF-5 function. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is a pyrimidine analog that interferes with nucleic acid synthesis. Its incorporation into RNA can disrupt RNA processing, affecting ATF-5 mRNA stability and translation. This interference with ATF-5 expression represents an indirect mechanism of inhibition through perturbation of nucleic acid metabolism. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 mitogen-activated protein kinase (MAPK) inhibitor. ATF-5 can be modulated by MAPK signaling pathways, and inhibition of p38 MAPK by SB203580 can disrupt these pathways, leading to the inhibition of ATF-5 through interference with its upstream regulatory signaling cascades. | ||||||