ASTL Inhibitors
ASTL inhibitors are chemical compounds that specifically target and inhibit the activity of the enzyme aspartate β-semialdehyde dehydrogenase (ASTL), which plays a critical role in the biosynthesis of essential amino acids. ASTL is a key enzyme in the aspartate pathway, catalyzing the conversion of aspartate-β-semialdehyde to homoserine, a precursor for the synthesis of lysine, threonine, methionine, and isoleucine. This pathway is present in microorganisms such as bacteria, fungi, and plants but is absent in mammals, making it an attractive focus for chemical research, particularly in studying metabolic processes and the regulation of amino acid synthesis. Inhibition of ASTL disrupts the biosynthesis of these essential amino acids, leading to the accumulation of intermediates and a reduction in the availability of downstream metabolic products, which are vital for cellular growth and function.
Structurally, ASTL inhibitors vary widely, with many acting as competitive inhibitors that mimic the enzyme's natural substrates or intermediate products. Others may bind to allosteric sites, causing conformational changes that reduce the enzyme's catalytic efficiency. Understanding the mechanism by which ASTL inhibitors interact with their target enzyme is crucial for advancing knowledge in enzymology and metabolic regulation. These compounds can also serve as valuable tools in biochemical studies aimed at elucidating the precise role of ASTL in different organisms. Investigations into ASTL inhibitors often involve exploring their binding affinities, structure-activity relationships, and effects on cellular metabolism, thereby contributing to the broader field of enzymatic inhibition and metabolic control in non-mammalian systems.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamidine | 618-39-3 | sc-233933 | 10 g | $286.00 | 1 | |
Benzamidine is a known inhibitor of serine proteases. ASTL is a serine protease, and benzamidine can inhibit its proteolytic activity by binding to its active site. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $50.00 $120.00 $420.00 $834.00 $1836.00 $4896.00 | 33 | |
AEBSF (4-(2-Aminoethyl) benzenesulfonyl fluoride) is a serine protease inhibitor and can directly inhibit ASTL by covalently modifying the serine residue in the active site of the enzyme, thus preventing substrate access. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $153.00 $255.00 $627.00 $1163.00 $2225.00 | 3 | |
Chymostatin is an inhibitor of chymotrypsin-like serine proteases and can inhibit ASTL by binding to the active site serine, thus blocking substrate cleavage. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin is a reversible inhibitor of serine and cysteine proteases. It inhibits ASTL by binding to the active site and preventing substrate hydrolysis. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $110.00 $400.00 $1615.00 | 51 | |
Aprotinin is a small protein protease inhibitor that can inhibit serine proteases, including ASTL, by forming a stable complex with the enzyme, thus inhibiting its activity. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
Gabexate Mesilate is a synthetic inhibitor of serine proteases and can inhibit ASTL by binding to its active site, preventing the interaction with its substrates. | ||||||
Camostat mesylate | 59721-29-8 | sc-203867 sc-203867A sc-203867B sc-203867C sc-203867D sc-203867E | 10 mg 50 mg 500 mg 1 g 10 g 100 g | $42.00 $179.00 $306.00 $612.00 $2040.00 $4386.00 | 5 | |
Camostat Mesilate is a synthetic serine protease inhibitor and can inhibit ASTL by binding to its active site, thus blocking protease activity. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $80.00 $300.00 | 4 | |
Nafamostat Mesilate is a synthetic serine protease inhibitor. It can inhibit ASTL by binding to its active site, thus preventing proteolysis. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
Although E-64 is primarily a cysteine protease inhibitor, it can inhibit ASTL by irreversibly binding to the active site serine, thereby blocking its protease activity. | ||||||