ASCC2 Activators
ASCC2 activators encompass a range of chemical entities that are designed to enhance the biological activity of ASCC2, a subunit of the Activating Signal Cointegrator Complex (ASCC). ASCC2 contributes to the regulation of transcription, and its function is critical for the proper assembly and operation of the ASCC, which has roles in various cellular processes, including the response to DNA damage. The activators of ASCC2 may exert their effects through a variety of mechanisms, such as direct interaction with the ASCC2 protein to stabilize its active form, facilitating the assembly of the ASCC complex, or enhancing the interaction between ASCC2 and other proteins or nucleic acids necessary for its function. The specificity of these activators is of paramount importance to ensure targeted modulation of ASCC2 without inadvertently affecting other components of the transcriptional machinery.
The discovery and optimization of ASCC2 activators are undertaken through an interdisciplinary approach that integrates insights from molecular biology, biochemistry, and chemical sciences. Initial efforts typically involve screening compound libraries to identify molecules that can increase ASCC2 activity. Such screenings may leverage in vitro assays that can detect enhancements in transcriptional activity or other functions associated with ASCC2. Once candidate activators are identified, they undergo a rigorous process of structural refinement to improve their potency, selectivity, and ability to interact with ASCC2 effectively. This refinement process utilizes a combination of structure-activity relationship (SAR) studies, computational modeling, and medicinal chemistry techniques. Detailed structural knowledge of ASCC2 obtained from methods such as X-ray crystallography or NMR spectroscopy is invaluable for designing activators that can bind precisely to the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol found in grapes and berries, may stimulate ASCC2 expression, potentially through the activation of sirtuins, proteins that play a crucial role in cellular health and gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, an active compound in turmeric, is postulated to upregulate ASCC2 expression. Its anti-inflammatory properties and capacity to modulate various cellular signaling pathways make it a potential candidate for this role. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
(-)-Epigallocatechin Gallate is a polyphenolic compound found in green tea. It may increase ASCC2 expression by modulating gene expression, potentially influencing the transcriptional activity of the ASCC2 gene. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid found in a variety of fruits and vegetables, could potentially induce ASCC2 expression. Its ability to influence cellular processes such as gene expression might play a role in this induction. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a phytoestrogen present in soybeans. It could stimulate ASCC2 expression by modulating hormone-responsive gene transcription, thus potentially influencing the activity of the ASCC2 gene. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane, a sulfur-rich compound found in broccoli, could potentially increase ASCC2 expression. It's known for its ability to enhance cellular detoxification pathways and antioxidant response, which might indirectly influence ASCC2 expression. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine, an isoquinoline alkaloid found in plants like Berberis, could potentially upregulate ASCC2 expression through its influence on cellular processes such as gene expression and metabolic regulation. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $51.00 $77.00 $102.00 $153.00 $2856.00 | 7 | |
Fisetin, a flavonoid present in many fruits, might induce ASCC2 expression by affecting gene expression and cellular signaling pathways, thus potentially influencing the transcription and translation processes of the ASCC2 gene. | ||||||
Pterostilbene, Pterocarpus marsupium | 537-42-8 | sc-203223 sc-203223A | 10 mg 100 mg | $207.00 $1173.00 | ||
Pterostilbene, a derivative of resveratrol found in blueberries, could stimulate ASCC2 expression by modulating cellular signaling pathways and gene expression, potentially influencing the regulatory mechanisms of the ASCC2 gene. | ||||||
(-)-Rhododendrol | 501-96-2 | sc-477170 | 2.5 mg | $430.00 | 1 | |
Rhododendrol, a tyrosinase inhibitor found in birch trees, might upregulate ASCC2 expression by impacting gene transcription and cell differentiation processes, potentially affecting the cellular levels of the ASCC2 protein. | ||||||