ASB-15 Inhibitors
ASB-15 inhibitors belong to a class of molecules that target the activity of the Ankyrin Repeat and SOCS Box protein 15 (ASB-15), which is part of the larger ASB family of proteins. These proteins are characterized by their ankyrin repeat domains and a SOCS box domain, allowing them to interact with a variety of cellular components. ASB-15 is involved in the regulation of protein degradation pathways by functioning as part of an E3 ubiquitin ligase complex, which facilitates the ubiquitination and subsequent degradation of specific target proteins. Inhibition of ASB-15 can affect the stability of these substrates, potentially leading to changes in various cellular processes that depend on protein turnover, such as signaling cascades, metabolic pathways, or structural protein maintenance.
ASB-15 inhibitors are of interest because of their ability to modulate these ubiquitin-mediated degradation processes. By inhibiting ASB-15 activity, the accumulation or depletion of certain proteins can be influenced, affecting various cellular functions. Researchers study ASB-15 inhibitors to explore their role in modulating protein interactions and turnover, with particular attention to how they impact intracellular signaling and homeostasis. Additionally, the study of ASB-15 inhibitors offers insight into the broader family of ASB proteins and their functions in cellular mechanisms such as protein localization and post-translational modifications. Understanding these interactions helps elucidate the complex networks of protein regulation within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may downregulate ASB-15 by inhibiting histone deacetylase, leading to an increase in acetylated histones and a subsequent decrease in transcriptional activity at the ASB-15 gene locus. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid could decrease the expression of ASB-15 by causing the accumulation of acetylated histones, which can lead to the repression of specific gene promoters, including that of ASB-15. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferases, 5-Azacytidine might promote the demethylation of the ASB-15 gene promoter, resulting in reduced transcriptional activity and lower ASB-15 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine could lead to the hypomethylation of the ASB-15 gene promoter, which is likely to result in a diminished initiation of transcription and a consequent decrease in ASB-15 protein levels. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit the ubiquitin-proteasome pathway, which might result in the accumulation of misfolded proteins and potentially trigger a stress response that reduces ASB-15 gene expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
As a proteasome inhibitor, MG-132 could cause an upregulation of cellular stress responses that may include the downregulation of ASB-15 as a means to cope with impaired proteostasis. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, by inhibiting the 26S proteasome, may lead to increased cellular stress and a compensatory decrease in the expression of certain proteins, potentially including ASB-15. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid can induce gene expression changes by activating retinoic acid receptors, which may bind to the promoter regions of target genes and repress the transcription of ASB-15. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone, through antagonism of aldosterone, could disrupt hormonal signaling pathways that are necessary for the expression of ASB-15, leading to its reduced expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is crucial for protein synthesis; this suppression might extend to the translation machinery responsible for ASB-15, thereby decreasing its synthesis. | ||||||