Arylsulfatase F Activators
Arylsulfatase F activators encompass a diverse array of chemical compounds that enhance the enzyme's functional activity through distinct biochemical pathways. The activation mechanisms involve either the upregulation of intracellular second messengers or direct modulation of specific kinase pathways. Some activators specifically elevate intracellular cyclic AMP levels, either by direct stimulation of adenylate cyclase or by inhibition of phosphodiesterases, leading to the activation of protein kinase A. This kinase, in turn, is known to phosphorylate numerous proteins, potentially including Arylsulfatase F, resulting in an increase in its enzymatic activity. Other compounds exert their effects by mimicking diacylglycerol, activating protein kinase C, which can initiate a phosphorylation cascade that may culminate in the enhanced activity of Arylsulfatase F. Additionally, there are activators that, by increasing intracellular calcium concentrations, could indirectly activate calcium-dependent kinases and phosphatases that are capable of modifying Arylsulfatase F, thereby increasing its activity.
Moreover, certain activators operate by modulating the sphingosine-1-phosphate receptor, which can lead to downstream signaling alterations that indirectly impact Arylsulfatase F activity. The inhibition of phosphodiesterase type 5 and other isoforms results in elevated levels of cyclic nucleotides, thus potentiating the activity of kinases such as protein kinase A and protein kinase G. These kinases may then phosphorylate and activate Arylsulfatase F, leading to an increase in its functional activity. In addition to these pathways, synthetic analogs of signaling lipids serve to activate protein kinase C, which may also result in the phosphorylation and subsequent activation of Arylsulfatase F.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
This diterpene acts on adenylate cyclase, leading to an increase in cyclic AMP (cAMP). Elevated levels of cAMP enhance protein kinase A (PKA) activity, which can phosphorylate and thus enhance the activity of Arylsulfatase F. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
As a diacylglycerol analog, PMA activates protein kinase C (PKC), which can phosphorylate a variety of proteins. PKC-mediated phosphorylation could increase the functional activity of Arylsulfatase F through signal transduction. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium concentration, which can activate calcium-dependent kinases and phosphatases, potentially influencing the phosphorylation state and activity of Arylsulfatase F. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that similarly to ionomycin, raises intracellular calcium levels, possibly affecting Arylsulfatase F activity through calcium-dependent signal transduction pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
This synthetic catecholamine agonist stimulates beta-adrenergic receptors, leading to increased cAMP production and activation of PKA, which could then activate Arylsulfatase F through phosphorylation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
A cAMP analog that can directly activate PKA without the need for adenylate cyclase activation, potentially leading to the phosphorylation and activation of Arylsulfatase F. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
Initially acting as a sphingosine-1-phosphate receptor modulator, it ultimately leads to the internalization and degradation of these receptors, which can alter signaling pathways that may activate Arylsulfatase F. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
This PDE5 inhibitor causes elevated levels of cAMP and cGMP, which might result in enhanced activity of kinases like PKA and PKG, indirectly activating Arylsulfatase F. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A selective inhibitor of PDE4, leading to increased cAMP levels and subsequent activation of PKA, which could phosphorylate and activate Arylsulfatase F. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, which increases levels of cAMP and cGMP, potentially enhancing the activity of Arylsulfatase F through kinase activation. | ||||||