ARVCF Activators
Activators are a distinctive class of chemical compounds that indirectly augment the functional activity of ARVCF, a protein involved in cell-cell adhesion and signaling within the cadherin-catenin complex. Compounds such as Forskolin, by increasing cAMP levels, and Epigallocatechin gallate, through its tyrosine kinase inhibition, indirectly support the stabilization and function of ARVCF within the cadherin complex.
PMA activates PKC, which promotes phosphorylation events that stabilize the complex, therebyenhancing ARVCF's role in cell adhesion. PI3K inhibitors like LY294002 and Wortmannin lead to beta-catenin's increased interaction with ARVCF, which is crucial for tight cell-cell adhesion. MEK inhibitor U0126 and p38 MAPK inhibitor SB203580 modulate specific pathways to upregulate adhesion molecules, including ARVCF. Thapsigargin and A23187 increase intracellular calcium, which is vital for ARVCF-mediated adhesion processes. Staurosporine, although a broad-spectrum kinase inhibitor, may have selective effects that enhance ARVCF's function. Sphingosine-1-phosphate signaling is critical for cytoskeletal organization, aiding ARVCF's role in the cadherin-catenin complex. Lastly, Genistein's inhibition of tyrosine kinase signaling can lead to a more stable and functional ARVCF within the cell adhesion complex.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylate cyclase activator, known to increase levels of cyclic AMP (cAMP) in cells. Elevated cAMP activates PKA, which can phosphorylate ARVCF, thereby enhancing its functional activity in cell-cell adhesion and signal transduction associated with the cadherin-catenin complex. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that inhibits multiple tyrosine kinases. By inhibiting competitive tyrosine kinase signaling, EGCG indirectly supports increased ARVCF activity by favoring beta-catenin stabilization and ARVCF's association with the cadherin complex. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a phorbol ester that activates protein kinase C (PKC). It enhances ARVCF function indirectly by promoting the phosphorylation of proteins within the cadherin-catenin complex, which can stabilize cell-cell adhesion where ARVCF is a critical component. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to alterations in cell signaling pathways, indirectly enhancing ARVCF's activity by affecting beta-catenin's cellular distribution and promoting its interaction with ARVCF in the cadherin-catenin complex. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that increases intracellular calcium levels. Elevated calcium can activate signaling pathways that stabilize cell-cell adhesion, indirectly enhancing ARVCF's activity as part of the cadherin-catenin complex. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that may preferentially influence pathways where ARVCF is involved by selectively lifting the inhibition of kinases that affect the cadherin-catenin complex, thereby indirectly enhancing ARVCF's functional role in adhesion. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a lipid signaling molecule that activates G-protein coupled receptors, leading to actin cytoskeletal rearrangements. This signaling can enhance the functional activity of ARVCF by promoting its interaction with the cadherin-catenin complex during cytoskeletal organization. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, indirectly enhancing ARVCF's role in the cadherin-catenin complex by activating calcium-dependent signaling pathways crucial for cell adhesion and signal transduction. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can shift signaling pathways toward those that favor ARVCF's functional role in the cadherin-catenin complex, thus indirectly supporting its activity in cell adhesion and signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that indirectly enhances ARVCF function by promoting beta-catenin stabilization and its interaction with ARVCF within the cadherin-catenin complex, leading to strengthened cell-cell adhesion. | ||||||