ARVCF Antibody (4B1): sc-23874
- ARVCF Antibody (4B1) is a mouse monoclonal IgG1 κ ARVCF antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 848-962 of ARVCF
- ARVCF Antibody (4B1) is recommended for detection of ARVCF of mouse, rat, human, canine and monkey origin by WB, IP, IF and IHC(P)
- Anti-ARVCF Antibody (4B1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ARVCF Antibody (4B1) for WB and IHC(P) applications. These reagents are now offered in bundles with ARVCF Antibody (4B1) (see ordering information below).
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ARVCF Antibody (4B1) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARVCF protein of mouse, rat, human, canine, and monkey origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. anti-ARVCF antibody (4B1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Armadillo repeat gene deleted in velo-cardiofacial syndrome (ARVCF) is a crucial member of the p120 (ctn) subfamily of Armadillo repeat proteins, consisting of 962 amino acids and featuring a coiled-coil domain along with ten tandem armadillo repeats. ARVCF plays a significant role in cell adhesion by binding to the cytoplasmic domain of M-cadherin through its armadillo repeat region, which is essential for maintaining the integrity of adherens junctions. Additionally, ARVCF competes with p120 for interaction with the juxtamembrane domain of E-cadherin, although ARVCF is present at a tenfold lower abundance than p120 across various cell types, making detection by immunofluorescence (IF) challenging unless overexpressed. ARVCF is dually localized to cell junctions and the nucleus, indicating potential distinct functions in different cellular compartments, similar to other Armadillo repeat proteins, including p120. This multifaceted role underscores ARVCF′s importance in cellular signaling and structural integrity, making ARVCF monoclonal antibody (4B1) a valuable tool for researchers studying cell adhesion and related pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ARVCF Antibody (4B1) References:
- Production and characterization of monoclonal antibodies to ARVCF. | Mariner, DJ., et al. 1999. Hybridoma. 18: 343-9. PMID: 10571264
- ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes. | Mariner, DJ., et al. 2000. J Cell Sci. 113 (Pt 8): 1481-90. PMID: 10725230
- Xarvcf, Xenopus member of the p120 catenin subfamily associating with cadherin juxtamembrane region. | Paulson, AF., et al. 2000. J Biol Chem. 275: 30124-31. PMID: 10899158
- The armadillo repeat region targets ARVCF to cadherin-based cellular junctions. | Kaufmann, U., et al. 2000. J Cell Sci. 113 (Pt 22): 4121-35. PMID: 11058098
- Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome. | Sirotkin, H., et al. 1997. Genomics. 41: 75-83. PMID: 9126485
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARVCF Antibody (4B1) | sc-23874 | 200 µg/ml | $316.00 | |||
ARVCF Antibody (4B1): m-IgG Fc BP-HRP Bundle | sc-526621 | 200 µg Ab; 10 µg BP | $354.00 | |||
ARVCF Antibody (4B1): m-IgG1 BP-HRP Bundle | sc-531994 | 200 µg Ab; 20 µg BP | $354.00 | |||
ARVCF Antibody (4B1) AC | sc-23874 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ARVCF Antibody (4B1) HRP | sc-23874 HRP | 200 µg/ml | $316.00 | |||
ARVCF Antibody (4B1) FITC | sc-23874 FITC | 200 µg/ml | $330.00 | |||
ARVCF Antibody (4B1) PE | sc-23874 PE | 200 µg/ml | $343.00 | |||
ARVCF Antibody (4B1) Alexa Fluor® 488 | sc-23874 AF488 | 200 µg/ml | $357.00 | |||
ARVCF Antibody (4B1) Alexa Fluor® 546 | sc-23874 AF546 | 200 µg/ml | $357.00 | |||
ARVCF Antibody (4B1) Alexa Fluor® 594 | sc-23874 AF594 | 200 µg/ml | $357.00 | |||
ARVCF Antibody (4B1) Alexa Fluor® 647 | sc-23874 AF647 | 200 µg/ml | $357.00 | |||
ARVCF Antibody (4B1) Alexa Fluor® 680 | sc-23874 AF680 | 200 µg/ml | $357.00 | |||
ARVCF Antibody (4B1) Alexa Fluor® 790 | sc-23874 AF790 | 200 µg/ml | $357.00 |