ART5 Inhibitors
ART5 inhibitors are a class of compounds that target various signaling pathways potentially involved in the functional regulation of ART5. These inhibitors act on different enzymes and receptors that are upstream of ART5 within the cell signaling networks. The inhibitors, such as LY294002 and Wortmannin, target the PI3K/AKT pathway which is a critical regulator of cell survival and proliferation. By inhibiting PI3K, these compounds prevent the downstream activation of AKT, which may be essential for the activation of ART5. As such, the inhibition of PI3K results in a reduction in ART5 activation due to the decreased phosphorylation and activation of necessary signaling components.
Similarly, inhibitors of the MAPK pathway, such as PD98059, SB203580, U0126, and Sorafenib, prevent the phosphorylation and activation of kinases that are central to the MAPK signaling cascade. These compounds effectively reduce the activity of ERK and p38, which could be crucial for the activation or function of ART5. Without the necessary MAPK activity, ART5 would remain inactive.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A specific inhibitor of PI3K. By inhibiting PI3K, LY294002 prevents the phosphorylation of AKT, leading to a reduction in AKT-mediated signaling. If ART5 functions downstream of AKT signaling, LY294002 would result in decreased ART5 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A selective inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. PD98059 blocks MEK's ability to activate ERK, thereby reducing ERK-mediated phosphorylation events. If ART5 depends on ERK signaling for its activation, then PD98059 would inhibit ART5's functional activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A pyridinyl imidazole compound that selectively inhibits p38 MAPK. By blocking the p38 MAPK pathway, SB203580 would inhibit the stress-activated signals that might be necessary for ART5's function, leading to a decrease in ART5 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
A specific mTOR inhibitor that binds to FKBP12, forming a complex that inhibits mTORC1. The inhibition of mTORC1 by Rapamycin would downregulate protein synthesis pathways that could include effectors of ART5, thereby inhibiting ART5 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
An irreversible inhibitor of PI3K. Wortmannin's action would inhibit the PI3K/AKT pathway, leading to a decrease in downstream signaling that could involve ART5, thus inhibiting its activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
A selective inhibitor of Src family tyrosine kinases. PP2 would inhibit Src kinase activity, potentially decreasing phosphorylation of substrates that activate pathways where ART5 is functionally involved, leading to reduced ART5 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
An inhibitor of MEK1/2, preventing the activation of MAPK/ERK. The inhibition of ERK activation by U0126 would lead to a decrease in downstream signaling required for ART5 activation or stability, culminating in inhibited ART5 activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
A broad-spectrum tyrosine kinase inhibitor that would inhibit BCR-ABL and Src family kinases. If ART5's activity is contingent upon these kinase signals, Dasatinib would lead to a decrease in ART5 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An anthrapyrazolone inhibitor of JNK. By inhibiting JNK, SP600125 would suppress JNK-mediated signaling events. If ART5 is activated by JNK signaling, then its activity would be inhibited by SP600125. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
A multi-kinase inhibitor that targets RAF kinases within the MAPK pathway. Sorafenib's inhibition of RAF would decrease downstream ERK signaling and any dependent ART5 activity, thus inhibiting ART5. | ||||||