ART1 Activators
ART1 Activators are a diverse array of compounds that enhance the functional activity of ART1, primarily through influencing substrate availability and modulating cellular signaling pathways. Direct activators like Nicotinamide Adenine Dinucleotide (NAD+), β-Nicotinamide Mononucleotide (β-NMN), Nicotinic Acid, and Nicotinamide Riboside (NR) enhance ART1 activity by increasing intracellular NAD+ levels, providing more substrate for ART1's key function of ADP-ribosylation. This enzymatic action of ART1 is crucial in various cellular processes, including signaling and stress response. Thymidine, by affecting nucleotide metabolism, also indirectly supports ART1 activity by potentially increasing NAD+ synthesis.
Indirect activators, including Isopentenyl Pyrophosphate (IPP) and Spermidine, impact ART1 activity by modulating cellular processes that ART1 is involved in, such as aging, autophagy, and cellular stress responses. Polyphenols and flavonoids like Resveratrol, Curcumin, and Quercetin enhance ART1 activity by affecting various cellular pathways, including stress response and inflammation, which may intersect with ART1's roles. Additionally, compounds like Sodium Butyrate and Epigallocatechin Gallate (EGCG) influence ART1 activity indirectly through their effects on histone deacetylation and oxidative stress, respectively. These activators collectively highlight the complex regulation of ART1, emphasizing its integration in diverse cellular pathways and the intricate balance of metabolic and signaling networks that govern its function.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+, as a substrate for ART1, can directly enhance its activity. ART1 catalyzes the transfer of ADP-ribose from NAD+ to target proteins, a key function in processes like cell signaling and stress response. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
β-NMN, a precursor of NAD+, can enhance ART1 activity by increasing intracellular NAD+ levels, thereby providing more substrate for ART1's ADP-ribosylation activity. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $49.00 $73.00 $270.00 $458.00 $1758.00 $114.00 | 16 | |
Thymidine, by influencing nucleotide metabolism, can indirectly enhance ART1 activity. Increased nucleotide synthesis may lead to higher NAD+ levels, indirectly supporting ART1's function. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic Acid is a precursor of NAD+, and its supplementation can enhance ART1 activity by increasing NAD+ availability for ADP-ribosylation reactions. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
NR, another NAD+ precursor, can enhance ART1 activity by raising intracellular NAD+ levels, providing more substrate for ART1’s enzymatic actions. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine, through its role in cellular aging and autophagy, might indirectly enhance ART1 activity by modulating cellular processes where ART1 is involved. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, can enhance ART1 activity indirectly through its effects on cellular stress response and survival pathways, potentially intersecting with ART1's roles. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, known for its anti-inflammatory properties, can indirectly enhance ART1 activity by modulating signaling pathways that may interact with ART1's function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, might enhance ART1 activity indirectly by influencing various cellular signaling pathways, including those involved in stress response where ART1 operates. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, a short-chain fatty acid, can indirectly enhance ART1 activity by affecting histone deacetylation, potentially influencing gene expression patterns related to ART1's function. | ||||||