ARRDC3 Activators
ARRDC3 activators comprise a spectrum of chemical entities that demonstrably enhance the functional activity of the ARRDC3 protein, a member of the arrestin domain-containing protein family. These compounds operate through distinct biochemical mechanisms to amplify the protein's role in the regulation of various cellular processes. For instance, a activator might function by stabilizing ARRDC3's interaction with membrane proteins, thereby facilitating its role in the modulation of receptor trafficking. Another class of activators could enhance ARRDC3's ability to interact with E3 ubiquitin ligases, leading to an increased ubiquitination of target proteins and influencing cellular signaling cascades that ARRDC3 is known to affect. The precise biochemical pathways through which these activators operate are myriad, but each pathway converges on the upregulation of ARRDC3's activity within the cell.
The second class of ARRDC3 activators may work indirectly by modulating the intracellular environment to be more conducive to ARRDC3's functions. This could involve the enhancement of lipid raft formation, a cellular microdomain where ARRDC3 is thought to exert its effects on protein trafficking. Additionally, these activators might increase the bioavailability of secondary messengers that are crucial for the activation of downstream signals that ARRDC3 is implicated in. By fine-tuning the cellular context, these chemicals ensure that ARRDC3 has a more pronounced impact on its associated pathways. It is through these multifaceted mechanisms that ARRDC3 activators are capable of potentiating the protein's inherent regulatory functions without altering its expression levels or directly modifying its structure.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases the intracellular levels of cAMP, which in turn can stimulate a cascade of phosphorylation events by activating protein kinase A (PKA). PKA can phosphorylate various targets, potentially enhancing the activity of ARRDC3 associated with cell signaling and endocytosis. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to an increase in cAMP levels within cells. Elevated cAMP activates PKA, which could indirectly increase ARRDC3 activity by phosphorylating proteins involved in ARRDC3-mediated pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
As a selective phosphodiesterase-4 inhibitor, Rolipram elevates intracellular cAMP levels, indirectly promoting PKA activation. This activation may enhance ARRDC3 function by influencing proteins that interact with or regulate ARRDC3. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels in cells, leading to PKA activation. PKA then potentially enhances the function of ARRDC3 through phosphorylation of associated regulatory proteins. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit various kinases, potentially reducing competitive signaling pathways and thus indirectly enhancing signaling events where ARRDC3 is involved, particularly in endocytosis and cell signaling. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, as a kinase inhibitor, may diminish competitive signaling pathways, indirectly allowing for the activation of processes in which ARRDC3 is implicated, such as vesicle formation and trafficking. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
As a selective inhibitor of phosphodiesterase-5, Zaprinast increases cAMP levels, possibly augmenting PKA activity and thus indirectly enhancing the functional role of ARRDC3. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin is known to inhibit various protein kinases, potentially lessening negative regulation on pathways involving ARRDC3 and indirectly enhancing its functional activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to inhibit kinase activity and could thereby reduce inhibitory signals on pathways where ARRDC3 is active, possibly enhancing its function in cellular signaling processes. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is known to activate certain receptor-mediated pathways that could lead to the activation of kinases in signaling cascades, indirectly influencing ARRDC3 activity through these pathways. | ||||||