ARL5A Inhibitors
ARL5A inhibitors as a chemical class are not well-defined due to the protein's relatively obscure nature and the current absence of direct inhibitors. However, the term ARL5A inhibitors could encompass a variety of compounds that interfere with the function or regulation of the ARL5A protein indirectly by targeting cellular pathways and processes that ARL5A is presumed to be part of. Since ARL5A belongs to the ARL family of GTPases, compounds that traditionally target other members of the GTPase superfamily, such as ARFs, Rac1, and Cdc42, can be considered as indirect inhibitors. These chemicals act by altering the GDP/GTP exchange or by inhibiting the interaction of these GTPases with their effectors or regulators. For instance, compounds like Brefeldin A and SecinH3 disrupt the GDP-GTP exchange cycle of ARFs, which could similarly affect ARL5A due to the functional parallels within this family.
Moreover, several inhibitors that target pathways involving cytoskeletal dynamics, such as the actin and microtubule networks, have been included due to the role that ARL proteins may play in cytoskeletal organization. Chemicals like Latrunculin A, CK-666, and Y-27632 act on different aspects of the cytoskeleton, altering the cellular functions where ARL5A is implicated. Additionally, inhibitors of signaling pathways, such as PI3K, MAPKGiven that ARL5A is a relatively less characterized member of the ADP-ribosylation factor-like (ARL) family of small GTPases
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Exo2 | 304684-77-3 | sc-215011 sc-215011A | 5 mg 25 mg | $89.00 $288.00 | 1 | |
Exo2 is known to inhibit the activation of ARF proteins by preventing the exchange of GDP for GTP. While its primary target is ARF6, it may impact other ARF family members, potentially affecting ARL5A's GTP binding and thus its function in nuclear dynamics and signaling during development. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A phosphoinositide 3-kinase (PI3K) inhibitor that could disrupt signaling pathways involving ARL5A, as some ARLs interact with components of the PI3K pathway. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3 targets cytohesin ARF GEFs, inhibiting ARF activation. The interference with ARF GEFs might indirectly affect ARL5A, influencing its GTPase activity and overall cellular function, especially in the context of nuclear dynamics and embryonic development signaling cascades. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts ARF activation by inhibiting the exchange of GDP for GTP. This compound affects various ARF proteins and could potentially interfere with ARL5A's function. Its impact might modulate ARL5A's roles in nuclear dynamics and embryonic signaling processes. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Inhibits Rac1 GTPase by blocking its activation; ARL5A, being a GTPase, could be affected through shared regulatory factors or pathways. | ||||||
PAC 1 | 315183-21-2 | sc-203174 sc-203174A | 10 mg 50 mg | $132.00 $536.00 | 1 | |
Selectively inhibits cytohesins, which are GDP-GTP exchange factors for ARFs; ARL5A function could be indirectly influenced due to its similarity to ARFs. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
A GTPase inhibitor, known to target dynamin, but may have off-target effects on other GTPases, such as ARL5A. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds to actin and prevents its polymerization; ARL5A, if involved in actin dynamics, could be indirectly inhibited by latrunculin A's effects. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
An inhibitor of the Arp2/3 complex which regulates actin polymerization; ARL5A's potential involvement in actin organization could be indirectly affected. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor that affects actin cytoskeleton dynamics; ARL5A's function could be indirectly influenced through altered actin dynamics. | ||||||