Acts as a chemical probe of intracellular transport. The compound has activities similar to Brefeldin A with membrane trafficking to the Golgi appartus, but seems to be more selective.
The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochem. J. 414, 471-484, (2008); Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep. 5, 596-601, (2004)
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