ARL3 Activators
ARL3 activators encompass a range of chemicals that can influence ARL3 function either directly or indirectly. GTPγS is a prominent example, being a non-hydrolyzable GTP analog, which has the capability to activate GTPases, emphasizing the importance of GTP binding and hydrolysis in modulating ARL3 function. In addition, AlF4- acts by mimicking the γ-phosphate of GTP in its transition state, reinforcing the significance of GTP turnover in ARL3 regulation.
Furthermore, the influence of broader cellular pathways is highlighted by compounds such as Forskolin and EGF. Forskolin underscores the importance of the cAMP pathway in modulating GTPase activity, while EGF denotes the diverse cellular responses that can be elicited by growth factors and how they can indirectly bear on ARL3's function. The impact of lipid signaling and phosphorylation on GTPase activity is also manifested by chemicals like U73122, Sodium Orthovanadate, and LY294002. These chemicals demonstrate that the regulation of GTPases such as ARL3 is not in isolation but is closely interwoven with the broader tapestry of cellular signaling and function. The interconnectedness of the cellular network is further elucidated by chemicals like MG-132, Okadaic acid, and Manumycin A, each playing distinct roles in protein stability, phosphorylation, and post-translational modifications, respectively.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
Non-hydrolyzable GTP analog that can bind to and activate GTPases including ARL3. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels which can indirectly influence GTPase pathways including those of ARL3. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Phosphatase inhibitor that can modulate phosphorylation patterns influencing GTPase activity, thus potentially affecting ARL3. | ||||||
Aluminum Fluoride | 7784-18-1 | sc-291881 sc-291881A | 10 g 50 g | $67.00 $250.00 | ||
Mimics the γ-phosphate of GTP in its transition state, often used to activate small GTPases. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that affects PI3K/Akt pathway, which can intersect with GTPase functions. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that can stabilize proteins indirectly affecting substrate availability for GTPases including ARL3. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits phosphatases, influencing phosphorylation and potentially modulating ARL3 indirectly. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Farnesyltransferase inhibitor; affects prenylation which is crucial for proper localization and function of GTPases. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $36.00 $88.00 $220.00 $436.00 | 8 | |
Iron chelator that affects cell cycle, potentially influencing GTPase-related processes. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Inhibits Rac1 GTPase; while it's an inhibitor of Rac1, it highlights the range of chemicals that can target GTPase function. | ||||||