ARL14EPL Activators
ARL14EPL activators encompass a variety of compounds that manipulate intracellular signaling pathways to enhance the protein's functional activity. For instance, specific activators work by directly stimulating adenylyl cyclase or by acting as beta-adrenergic receptor agonists, both leading to an increase in cAMP levels within the cell. This rise in cAMP acts as a secondary messenger that is pivotal in modulating the activity of various proteins, including ARL14EPL. The activation of protein kinase C through certain compounds also plays a critical role, as this kinase can phosphorylate and modulate the activity of a plethora of proteins, potentially including ARL14EPL. Moreover, inhibition of phosphodiesterases by certain agents prevents cAMP breakdown, thus sustaining its levels and indirectly promoting the activation of ARL14EPL through prolonged cAMP signaling.
Other activators exert their effects by altering intracellular calcium concentrations, either through direct ionophoresis or by agonizing calcium channels, which can trigger calcium-mediated signaling cascades with the potential to indirectly enhance the activity of ARL14EPL. Furthermore, certain compounds are capable of inhibiting enzymes such as glycogen synthase kinase-3, leading to the modulation of protein activity within various signaling pathways. Additionally, epigenetic mechanisms are influenced by compounds that inhibit histone deacetylase, leading to changes in gene expression and potentially affecting ARL14EPL activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly stimulates adenylyl cyclase, increasing intracellular cAMP levels. ARL14EPL activity is enhanced in a cAMP-dependent manner as cAMP serves as a secondary messenger that can modulate various protein functions. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A non-selective beta-adrenergic receptor agonist that leads to the activation of adenylyl cyclase and subsequent increase in cAMP levels, indirectly promoting ARL14EPL activation through cAMP signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC) which can modulate the activity of various proteins including ARL14EPL by phosphorylation, thereby potentially altering its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective inhibitor of phosphodiesterases (PDEs) that prevents the breakdown of cAMP, indirectly leading to sustained cAMP levels that could enhance ARL14EPL activation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Acts as a protein synthesis inhibitor and activates stress-activated protein kinases, which could then modulate the activity of proteins including ARL14EPL. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases potentially influencing ARL14EPL activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that raises intracellular calcium concentration, triggering calcium-mediated signaling cascades that could indirectly activate ARL14EPL. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits glycogen synthase kinase-3 (GSK-3), which may lead to the modulation of various signaling pathways and proteins, including ARL14EPL. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A histone deacetylase inhibitor that can lead to changes in gene expression and protein function, potentially affecting the activity of ARL14EPL through epigenetic mechanisms. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A selective inhibitor of PDE4, leading to increased cAMP levels, which could subsequently enhance ARL14EPL function as part of the cAMP signaling pathway. | ||||||