ARHGEF38 Activators
Common ARHGEF38 Activators include, but are not limited to Y-27632 dihydrochloride CAS 129830-38-2, H-1152 dihydrochloride CAS 451462-58-1, NSC 23766 CAS 733767-34-5, EHop-016 CAS 1380432-32-5 and GGTI 298 CAS 1217457-86-7.
ARHGEF38, an abbreviation for Rho Guanine Nucleotide Exchange Factor 38, is a protein that plays a pivotal role in cellular signaling, particularly in the regulation of the Rho family of GTPases. GTPases are known to control a multitude of cellular processes, including cell morphology, migration, endocytosis, and cell cycle progression. The primary function of ARHGEF38 is to facilitate the exchange of GDP for GTP on Rho proteins, thereby activating them. This activation initiates a cascade of intracellular events that lead to various cellular outcomes. Given the centrality of the Rho GTPases in cellular functions, the regulation and activation of these proteins, especially by proteins like ARHGEF38, are of paramount importance.
Activators of ARHGEF38 are molecules or compounds that can enhance or stimulate the function or expression of the ARHGEF38 protein. These activators can increase the protein's efficiency in facilitating GDP-GTP exchange on Rho GTPases or can promote greater expression or stability of ARHGEF38 within cells. The mechanisms through which these activators operate can be varied, ranging from directly binding to ARHGEF38 to altering its conformation for improved interaction with Rho proteins, to indirectly modulating its transcriptional or translational levels. By enhancing ARHGEF38's activity, these activators can profoundly influence the cellular landscape, particularly the intricate balance of Rho GTPase activation and the subsequent cellular responses. Understanding the dynamics and implications of ARHGEF38 activators can provide deeper insights into the sophisticated world of cellular signaling and the Rho GTPase-mediated cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
By inhibiting ROCK, Y-27632 could potentially disrupt downstream signaling, possibly leading to a compensatory increase in ARHGEF38 expression to restore Rho signaling balance. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $102.00 $357.00 | 7 | |
H-1152 could potentially cause a compensatory activation of ARHGEF38 expression to maintain Rho signaling pathway activity. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
By inhibiting Rac1, NSC 23766 might potentially induce ARHGEF38 expression as a compensatory response to maintain Rho GTPase signaling activity. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $78.00 | ||
Inhibition of Rac GTPase by EHop-016 might potentially trigger a compensatory response, possibly inducing ARHGEF38 expression to restore signaling balance. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $189.00 $822.00 | 2 | |
By inhibiting geranylgeranyltransferase I, GGTI-298 could potentially affect the prenylation and activity of Rho GTPases, possibly leading to ARHGEF38 expression induction as a compensatory mechanism. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $61.00 $85.00 | 4 | |
By inhibiting Aurora kinase, Tozasertib might affect cell signaling pathways, potentially leading to a compensatory induction of ARHGEF38 expression to restore signaling homeostasis. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
By inhibiting Cdc42, ZCL278 might potentially trigger a compensatory activation of ARHGEF38 expression to maintain Rho signaling activity. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 could potentially induce a compensatory response, possibly leading to ARHGEF38 expression activation to maintain Rho signaling balance. | ||||||
AZA1 | 1071098-42-4 | sc-507497 | 10 mg | $600.00 | ||
By inhibiting Rho kinase, AZA1 might potentially trigger a compensatory activation of ARHGEF38 expression to maintain Rho GTPase signaling activity. | ||||||
Rhosin | 1173671-63-0 | sc-507401 | 25 mg | $555.00 | ||
Rhosin hydrochloride might potentially trigger a compensatory activation of ARHGEF38 expression to restore Rho signaling balance. | ||||||