ARHGEF38 Inhibitors
ARHGEF38 inhibitors represent a class of chemical compounds that target and inhibit the activity of the ARHGEF38 protein. ARHGEF38, or Rho guanine nucleotide exchange factor 38, is a member of the RhoGEF family, which plays a significant role in modulating the activity of Rho GTPases. Rho GTPases are small signaling proteins that regulate various cellular processes, including cytoskeletal dynamics, cell migration, and intracellular signaling pathways. ARHGEF38, in particular, facilitates the exchange of GDP for GTP on Rho GTPases, activating them and driving downstream cellular functions. By inhibiting ARHGEF38, these chemical agents block the protein's ability to activate Rho GTPases, leading to altered cell signaling, changes in cytoskeletal arrangement, and modulation of other related cellular activities. This inhibition can have wide-ranging effects on cellular function, depending on the specific context in which ARHGEF38 operates.
The specificity and mechanism of action of ARHGEF38 inhibitors are crucial for understanding how they interfere with signaling pathways. These inhibitors may act directly on the ARHGEF38 protein or interfere with its interaction with other cellular components. The precise binding and inhibition mechanisms often involve targeting the active site or specific domains essential for the guanine nucleotide exchange factor (GEF) activity of ARHGEF38. Additionally, ARHGEF38 inhibitors may affect other proteins or pathways indirectly due to the interconnected nature of cellular signaling networks. Such inhibitors are important for studying the broader biological role of ARHGEF38 and provide tools for exploring the molecular underpinnings of various cellular processes, particularly those governed by Rho GTPase activity and regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A selective inhibitor of ROCK (Rho-associated protein kinase), downstream of RhoA activation. ARHGEF38 is a Rho guanine nucleotide exchange factor (GEF), and inhibition of ROCK leads to reduced RhoA-mediated signaling, thus potentially diminishing ARHGEF38-induced actin cytoskeletal changes. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
Specifically disrupts the interaction between Rac1 and its GEFs, such as ARHGEF38. By preventing this interaction, NSC23766 indirectly reduces ARHGEF38-mediated Rac1 activation, impacting cell motility and morphology. | ||||||
CCG-1423 | 285986-88-1 | sc-205241 sc-205241A | 1 mg 5 mg | $30.00 $90.00 | 8 | |
An inhibitor targeting the transcriptional activity of serum response factor (SRF), which is downstream of RhoA signaling. Since ARHGEF38 activates RhoA, CCG-1423 may indirectly reduce ARHGEF38's influence on gene expression driven by SRF. | ||||||
ITX 3 | 347323-96-0 | sc-295214 sc-295214A | 10 mg 50 mg | $145.00 $615.00 | ||
A selective inhibitor of Trio, another GEF protein, but it may indirectly affect ARHGEF38 by altering the balance of active GEFs within the cell and thereby modulating the signaling pathways ARHGEF38 is involved in. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $209.00 $872.00 | 12 | |
A potent Rac1 inhibitor that binds and stabilizes Rac1 in an inactive state. As ARHGEF38 is implicated in the activation of Rac1, EHT 1864's action can result in decreased ARHGEF38-mediated cell motility and invasion. | ||||||
CASIN | 425399-05-9 | sc-397016 | 10 mg | $460.00 | 1 | |
Inhibits Cdc42 activity, another small GTPase involved in actin cytoskeleton reorganization. Although ARHGEF38 is not a direct GEF for Cdc42, the inhibition of Cdc42 can indirectly impact ARHGEF38-related pathways, resulting in reduced cytoskeletal dynamics. | ||||||
GSK 269962 | 850664-21-0 | sc-363279 sc-363279A | 10 mg 50 mg | $300.00 $1000.00 | 1 | |
A ROCK inhibitor like Y-27632, it prevents the phosphorylation of downstream targets of RhoA, potentially impacting the signaling cascade involving ARHGEF38 and thereby modulating actin filament assembly. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
A compound that disrupts the interaction between Cdc42 and its specific GEFs. While ARHGEF38 is not a Cdc42 GEF, this disruption can indirectly influence the overall signaling milieu that ARHGEF38 functions within. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
A Cdc42 inhibitor which, by rendering Cdc42 inactive, may indirectly affect ARHGEF38 activity due to the interconnected nature of Rho GTPase signaling pathways in which ARHGEF38 participates. | ||||||