GSK 269962 CAS: 850664-21-0
MF: C29H30N8O5
MW: 570.60
A potent inhibitor of Rho kinase (ROCK).

GSK 269962 (CAS 850664-21-0)

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Alternate Names: N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide
Application: GSK 269962 is a potent inhibitor of Rho kinase (ROCK)
CAS Number: 850664-21-0
Molecular Weight: 570.60
Molecular Formula: C29H30N8O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

GSK 269962 is a potent rho kinase (ROCK) inhibitor (IC50 = 1.6 and 4 nM for ROCK1 and ROCK2, respectively). This compound displays greater than 30-fold selectivity for ROCK against a panel of Ser/Thr kinases. GSK 269962 induces vasodilation in rat aorta (IC50 = 35 nM).

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol with gentle warming (10 mM).
Storage :
Store at 4° C
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
recombinant human ROCK1: IC50 = 1.6 nM (human); recombinant human ROCK2: IC50 = 4 nM (human); : IC50 = 35 nM
Ki Data :
Ribosomal protein S6 kinase 1: Ki= 3.16 nM (human); Protein kinase C delta: Ki= 5.01 nM (human); Protein kinase N2: Ki= 25.12 nM (human)
pK Values :
pKa: 13.19 (Predicted), 6.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16095342
MDL Number :
MFCD09970310
SMILES :
CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6

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Certificate of Analysis

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GSK 269962 (CAS 850664-21-0)  Product Citations

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PMID: # 29601578  Allam, O.|Samarani, S.|Mehraj, V.|Jenabian, MA.|Tremblay, C.|Routy, JP.|Amre, D.|Ahmad, A.| et al. 2018. PLoS ONE. 13: e0194185.

Citations 1 to 1 of 1 total
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