ARHGEF10 Activators
ARHGEF10 (Rho guanine nucleotide exchange factor 10) is a protein that in humans is encoded by the ARHGEF10 gene. This protein is part of the Rho GEF family, which functions to activate Rho GTPases by facilitating the exchange of GDP for GTP. Rho GTPases are critical regulators of the actin cytoskeleton and are involved in various cellular processes, including cell morphology, vesicular trafficking, cell migration, and cell cycle progression.
ARHGEF10 specifically activates the RhoA GTPase, a member of the Rho family, playing a significant role in the regulation of neuronal morphology and the development of the nervous system. It has been implicated in the process of myelination in peripheral nerves, which is essential for the proper conduction of electrical signals in the nervous system. Mutations or alterations in the ARHGEF10 gene have been linked to slowed nerve conduction velocity and other neurological disorders.The protein is also thought to contribute to the maintenance of the cytoskeletal architecture required for axon guidance and neuronal growth. By influencing the dynamics of actin and microtubules, ARHGEF10 is essential for the structural and functional plasticity of neurons.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
May regulate ARHGEF10 expression by activating retinoic acid receptors that are involved in neuronal development. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Could modulate gene expression related to the cytoskeleton and neuronal growth through its signaling effects. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
As a kinase inhibitor, genistein may impact signaling pathways that regulate cytoskeletal genes such as ARHGEF10. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
May affect transcription factors involved in neuronal development and cytoskeletal organization, potentially influencing ARHGEF10. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Might regulate ARHGEF10 expression via sirtuin activation, which can influence cellular stress response pathways. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Could upregulate ARHGEF10 expression by altering DNA methylation and chromatin structure around the gene. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, it may promote transcriptional activation of genes involved in neural function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Might influence gene expression by inhibiting HDACs, potentially leading to changes in ARHGEF10 transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By increasing cAMP levels, forskolin could affect pathways that regulate neuronal genes, including ARHGEF10. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Its active form may regulate gene expression related to nerve function and growth, which could include ARHGEF10. | ||||||