apoL7e Inhibitors
Chemical inhibitors of apolipoprotein L 7e utilize varied biochemical mechanisms to inhibit the protein's function. Marimastat, by inhibiting metalloproteinases, prevents the cleavage and activation of apolipoprotein L 7e, thereby inhibiting its function. Similarly, E-64 acts on cysteine proteases, which are responsible for the post-translational modification of the protein, resulting in the prevention of its activation or functional conformational changes. Leupeptin, which targets both serine and cysteine proteases, can interfere with the activation process of apolipoprotein L 7e by blocking essential proteolytic steps. Pepstatin A, an aspartyl protease inhibitor, can impede the maturation process of apolipoprotein L 7e, affecting its interaction within lipid metabolism.
Further down the line of intracellular processing, Bafilomycin A1 disrupts vacuolar H+-ATPases, leading to the inhibition of the intracellular trafficking of apolipoprotein L 7e, thereby impeding its transport to the necessary cellular location. MG-132 prevents the degradation of misfolded apolipoprotein L 7e by inhibiting the proteasome, leading to the accumulation of non-functional forms of the protein. Phenylarsine Oxide, by inhibiting tyrosine phosphatases, can alter phosphorylation-dependent signaling pathways necessary for the activity of the protein. LY294002 and Wortmannin, both PI3K inhibitors, can disrupt signaling pathways that are essential for the function of apolipoprotein L 7e. Z-VAD-FMK targets caspases, which can prevent the apoptosis-associated degradation of the protein, while ALLN inhibits calpains, potentially leading to the accumulation of inhibitory fragments of apolipoprotein L 7e. Lastly, Gö6976 inhibits protein kinase C, which can prevent phosphorylation-dependent processes essential for the protein's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $165.00 $214.00 $396.00 $617.00 $4804.00 | 19 | |
Marimastat inhibits metalloproteinases, which may be involved in the cleavage and activation of apolipoprotein L 7e, leading to its functional inhibition by preventing its proper processing and maturation. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64 inhibits cysteine proteases that could be responsible for the post-translational modification of apolipoprotein L 7e, thus causing inhibition by averting the protein's activation or functional conformational changes. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin targets serine and cysteine proteases, which may directly interfere with the activation process of apolipoprotein L 7e, hence inhibiting its function by blocking essential cleavage steps. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 disrupts vacuolar H+-ATPases, which could lead to an inhibition of the intracellular trafficking of apolipoprotein L 7e, thereby functionally inhibiting the protein by impeding its transport to the necessary cellular location. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 inhibits the proteasome, preventing the degradation of misfolded or improperly formed apolipoprotein L 7e, leading to its functional inhibition as the accumulation of non-functional protein can interfere with the proper protein population. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
Phenylarsine Oxide inhibits tyrosine phosphatases, which could alter phosphorylation-dependent signaling pathways necessary for the activity of apolipoprotein L 7e, leading to functional inhibition of the protein. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, a kinase involved in signaling pathways that could be necessary for the functional activity of apolipoprotein L 7e, inhibiting the protein by disrupting these pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of PI3K, leading to the inhibition of downstream signaling pathways that are essential for the function of apolipoprotein L 7e, thereby inhibiting the protein's function by halting necessary signaling events. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
Z-VAD-FMK inhibits caspases, which may prevent the apoptosis-associated degradation of cells expressing apolipoprotein L 7e, inhibiting the protein's function by stabilizing non-functional forms within the cell. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Gö6976 inhibits protein kinase C, which could prevent phosphorylation-dependent processes that are necessary for the proper function of apolipoprotein L 7e, resulting in the functional inhibition of the protein. | ||||||