Apolipoprotein L (ApoL) Activators
Apolipoprotein L (ApoL) is a family of proteins primarily involved in lipid transport and metabolism. They play key roles in cellular processes such as the formation of lipoprotein particles, which are essential for lipid distribution within the body. ApoL proteins may also interact with other cellular components, affecting pathways that govern apoptosis and autophagy. The activity and expression of ApoL proteins can be influenced by various factors, including hormones, nutritional status, and small molecules that target lipid metabolism.
Apolipoprotein L (ApoL) activators generally work through a variety of mechanisms, including but not limited to, epigenetic modulation, inhibition of opposing pathways, and altering substrate availability. For example, some molecules in this class may function as DNA methyltransferase inhibitors or histone deacetylase inhibitors, thereby affecting the epigenetic landscape around the ApoL gene to upregulate its expression. Others may target metabolic pathways or signaling cascades that intersect with ApoL function, indirectly causing an increase in ApoL levels or activity. It is also worth noting that members of this chemical class can be highly selective or broad-spectrum, depending on their targets and mechanisms of action.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
As a PI3K inhibitor, it may affect lipid metabolism and potentially influence ApoL | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor may upregulate the expression of genes encoding ApoL proteins. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor that could upregulate genes responsible for ApoL protein expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase that could influence cAMP levels, and thus might affect ApoL protein expression or activity indirectly. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
A PPAR-γ agonist that might influence lipid metabolism and thereby potentially affect ApoL proteins. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Known to activate AMP-activated protein kinase (AMPK), which can promote fatty acid oxidation. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
A PPAR-α agonist known to upregulate the expression of apolipoproteins, which are involved in lipid transport. | ||||||
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $47.00 $92.00 $5826.00 | 3 | |
A critical substrate for lipid metabolism pathways, increased levels could indirectly influence ApoL levels by providing more substrates for lipoprotein formation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Known for its regulatory roles in lipid and carbohydrate metabolism, it could indirectly influence ApoL levels or activity. | ||||||