APOBEC2 Activators
APOBEC2 activators belong to a category of compounds that modulate the activity of a specific enzyme known as APOBEC2, or apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2. This enzyme is part of the larger APOBEC family, which plays a significant role in cellular genetic material editing processes. APOBEC2, in particular, has been studied for its involvement in various biological functions, including but not limited to, the editing of RNA molecules. The activators of this enzyme are therefore of interest for their capacity to enhance the natural activity of APOBEC2 within cells.
The chemical structure and properties of APOBEC2 activators can vary, but they are designed or identified based on their ability to increase the catalytic activity of APOBEC2. The mechanism by which these activators work may involve direct interaction with the enzyme, leading to a conformational change that results in increased efficiency of the enzyme's activity. Alternatively, activators may interact with regulatory molecules or cellular structures that modulate the function of APOBEC2 indirectly. The exact molecular processes and interactions depend on the specific activator in question and require a deep understanding of biochemistry and molecular biology to fully elucidate. Research in this area is driven by a fascination with the fundamental workings of cellular machinery and the complex choreography of molecular interactions that sustain life.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels within the cell. Elevated cAMP activates protein kinase A (PKA), which can then phosphorylate various target proteins. Since APOBEC2 is involved in DNA editing, PKA-mediated phosphorylation can enhance APOBEC2 activity by altering its interaction with DNA substrates. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, enzymes responsible for the breakdown of cAMP. By preventing cAMP degradation, IBMX indirectly maintains high levels of PKA activity, which can lead to enhanced APOBEC2 phosphorylation and activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits DNA methyltransferases, which could lead to altered DNA methylation patterns. This may indirectly affect APOBEC2 function by changing the availability of DNA substrates suitable for APOBEC2-mediated editing. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a NAD+-dependent deacetylase. SIRT1 can deacetylate histones, which leads to changes in chromatin structure, potentially increasing access of APOBEC2 to its DNA targets. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is an activator of the transcription factor NF-κB. Activation of NF-κB can lead to the transcription of genes involved in the immune response, some of which could interact with or have downstream effects on APOBEC2 function. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol inhibits Syk kinase, which is part of signaling pathways involved in B cell receptor signaling. This inhibition could alter the function of immune cells and potentially enhance APOBEC2 activity in the context of immune surveillance. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which can affect transcription factors and gene expression patterns. By altering gene expression, it could indirectly increase the availability of co-factors required for APOBEC2 function or alter the cellular context in which APOBEC2 operates. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which leads to hyperacetylation of histones and a more open chromatin state. This can enhance the access of APOBEC2 to its DNA targets for cytidine deamination. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor, which interferes with cell cycle progression. By affecting the cell cycle, it could indirectly increase APOBEC2 activity by altering the availability of substrates during the DNA repair processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, which blocks the MAPK/ERK pathway. This could lead to altered cell signaling environments that enhance APOBEC2 activity due to changes in the balance of cell cycle regulation and DNA repair mechanisms. | ||||||