Angptl4 Inhibitors
Angiopoietin-like 4 (Angptl4) inhibitors belong to a class of small molecules that target a specific protein called Angptl4. Angptl4 is a glycoprotein known for its crucial role in regulating lipid metabolism, angiogenesis, and glucose homeostasis. It is primarily produced by various tissues, including the liver, adipose tissue, and skeletal muscles. In its natural state, Angptl4 acts as a multifunctional protein, playing a pivotal role in maintaining lipid and glucose balance in the body. However, when overexpressed or dysregulated, Angptl4 can contribute to metabolic disorders such as obesity, dyslipidemia, and insulin resistance.
Angptl4 inhibitors are designed to modulate the activity of Angptl4, either by directly binding to the protein or by interfering with its downstream signaling pathways. By inhibiting Angptl4, these compounds can potentially mitigate its detrimental effects on lipid metabolism and glucose regulation. This class of inhibitors has garnered significant attention in the field of metabolic research due to their potential to combat obesity and associated metabolic disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is found in the spice turmeric and has been shown to modulate various signaling pathways, potentially leading to reduced expression of pro-inflammatory genes and proteins, including Angptl4. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a compound found in red wine, has antioxidant properties and may downregulate Angptl4 expression as part of its effects on lipid metabolism and inflammation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid present in many fruits and vegetables, has been observed to influence gene expression and protein levels, potentially reducing Angptl4 expression through anti-inflammatory mechanisms. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a soy-derived isoflavone that may modulate lipid metabolism and inflammation, leading to the downregulation of Angptl4 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a major component of green tea and has been shown to affect lipid metabolism and inflammation, potentially reducing Angptl4 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, is known for its antioxidant and anti-inflammatory properties, potentially influencing Angptl4 expression. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Fisetin is a flavonol found in various fruits and vegetables and has demonstrated potential in modulating inflammation and gene expression, which may include downregulation of Angptl4. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin is a flavonoid that possesses anti-inflammatory properties and may play a role in the downregulation of Angptl4 expression through its effects on cellular signaling pathways. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol, a flavonoid present in various plants, has anti-inflammatory and antioxidant properties, potentially influencing the expression of proteins like Angptl4. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavonoid found in many fruits and vegetables and has been shown to possess anti-inflammatory properties, potentially leading to reduced Angptl4 expression. | ||||||