ANG V Activators
Angiogenin, ribonuclease family member 5 (ANG V), is an intriguing protein that plays a significant role in the molecular orchestration of angiogenesis-the process by which new blood vessels form from existing ones. As a member of the ribonuclease (RNase) A superfamily, ANG V is primarily involved in the growth and migration of endothelial cells, which are critical for the development of the vascular network. The expression of ANG V is a finely tuned process, responsive to a multitude of intra- and extracellular signals, ensuring that the delicate balance of vessel growth and maintenance is preserved. Understanding the regulation of ANG V expression is of fundamental interest for elucidating the mechanisms governing angiogenesis in physiological contexts.
Several chemical compounds have been identified as potential inducers of ANG V expression, each interacting with distinct cellular pathways to upregulate the protein's synthesis. For instance, chemicals that simulate hypoxic conditions in cells, such as cobalt chloride, can induce ANG V expression by stabilizing transcription factors that are sensitive to oxygen levels. Similarly, histone deacetylase inhibitors like sodium butyrate alter chromatin structure, making the genomic regions coding for ANG V more accessible for transcriptional machinery, thereby enhancing ANG V expression. Other compounds, such as retinoic acid, are known to trigger cellular differentiation signals that include the upregulation of ANG V, contributing to the complex network of signals that govern angiogenesis and cellular development. Lithium chloride, which affects the Wnt signaling pathway, also exemplifies how intracellular signaling cascades can be modulated to influence ANG V expression. These chemicals, through their interaction with various cellular components and pathways, illuminate the intricate web of regulatory mechanisms that control the expression of critical proteins like ANG V. Understanding these pathways offers insights into the fundamental processes of cell signaling and gene expression regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Cobalt chloride can simulate hypoxic conditions, potentially upregulating ANG V expression via stabilization of hypoxia-inducible factors that enhance transcription of hypoxia-responsive genes. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $82.00 $295.00 $367.00 $764.00 | 25 | |
By inhibiting prolyl hydroxylase, dimethyloxalylglycine may lead to the accumulation of hypoxia-inducible factors, which could upsurge ANG V expression as a cellular adaptation to hypoxia. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide can provoke an increase in ANG V expression through its ability to alter the secretion of inflammatory cytokines, potentially creating an environment conducive to angiogenesis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA can activate protein kinase C, which may trigger a signaling cascade leading to the upsurge in transcriptional activity of genes like ANG V. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
As a beta-adrenergic agonist, isoproterenol could prompt an increase in intracellular cAMP, leading to the activation of cAMP response element-binding protein (CREB) and subsequent upsurge in ANG V expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may prompt endothelial cells to upregulate ANG V expression due to its antioxidative properties, which can precondition cells to promote angiogenesis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has the potential to induce ANG V expression by inhibiting transcription factors like NF-κB, which are involved in the suppression of inflammatory responses at the genomic level. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Exposure to hydrogen peroxide can lead to oxidative stress, which may trigger a compensatory response in cells, including the upregulation of ANG V to facilitate tissue repair processes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, as a histone deacetylase inhibitor, can cause histone hyperacetylation leading to an open chromatin structure and a subsequent surge in ANG V gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-azacytidine could induce hypomethylation of the ANG V gene promoter, leading to enhanced gene expression. | ||||||