Ang-1 Inhibitors
Ang-1 (Angiopoietin-1) inhibitors are a class of chemical compounds that specifically target the Angiopoietin-1 protein, a critical regulator of vascular development and remodeling. Ang-1 is known to bind to the Tie2 receptor, a tyrosine kinase receptor expressed predominantly on endothelial cells. This interaction activates signaling pathways that promote the stability and integrity of blood vessels. Inhibitors of Ang-1 disrupt its ability to bind to the Tie2 receptor, thereby modulating the signaling pathways that Ang-1 influences. By blocking or altering the Ang-1/Tie2 interaction, these inhibitors can impact endothelial cell behavior, including aspects of cell migration, adhesion, and vessel maturation.
The structural diversity of Ang-1 inhibitors allows for various mechanisms of action. Some inhibitors are small molecules that directly bind to the Ang-1 protein, preventing its interaction with Tie2 by occupying critical binding domains. Others may act as allosteric modulators, altering the protein's conformation and reducing its ability to engage the receptor. Additionally, peptide-based inhibitors or engineered analogs may mimic certain features of Ang-1, competitively inhibiting the protein's natural function. These inhibitors provide valuable tools for studying the signaling pathways regulated by Ang-1, particularly in processes involving vascular biology. Through the use of Ang-1 inhibitors, researchers gain deeper insights into the molecular mechanisms that govern vessel formation, stability, and maintenance, as well as how endothelial cells respond to environmental and biochemical cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Sunitinib is a small molecule multi-targeted receptor tyrosine kinase inhibitor that has been shown to inhibit the angiogenic activity of AngptIt targets various receptors involved in angiogenesis, including Tie2, and can indirectly inhibit the effects of Angpt1. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Imatinib inhibits c-Abl kinase, which is known to interact with and phosphorylate Ang-1. By blocking c-Abl, Imatinib indirectly downregulates Ang-1 phosphorylation and signaling, thus modulating its activity. This occurs through the interruption of a key regulatory node in the signaling network. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib, a dual Src/Abl kinase inhibitor, affects signaling pathways downstream of c-Abl. As c-Abl has regulatory interactions with Ang-1, Dasatinib indirectly influences Ang-1 activity by disrupting these signaling cascades. The inhibition of c-Abl, a known modulator of Ang-1 function, is a crucial aspect of Dasatinib's mechanism. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that affects multiple signaling pathways. By targeting kinases involved in Ang-1 regulation, such as PKC and others, Staurosporine indirectly modulates Ang-1 activity. The impact is exerted through the disruption of interconnected signaling cascades that converge on Ang-1 regulation. | ||||||
Sunitinib Malate | 341031-54-7 | sc-220177 sc-220177A sc-220177B | 10 mg 100 mg 3 g | $197.00 $520.00 $1093.00 | 4 | |
Sunitinib Malate inhibits receptor tyrosine kinases, including those involved in pathways interacting with Ang-1 signaling. By targeting key kinases, Sunitinib indirectly influences Ang-1, disrupting the network of signals that regulate its function. The impact extends to the modulation of downstream events governed by Ang-1 activity. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib inhibits multiple kinases involved in angiogenesis, affecting pathways intersecting with Ang-1 signaling. By disrupting these signaling cascades, Sorafenib indirectly modulates Ang-1 activity, altering the network of events regulated by Ang-1 in the context of angiogenesis and related processes. | ||||||
PKC-412 | 120685-11-2 | sc-200691 sc-200691A | 1 mg 5 mg | $52.00 $114.00 | 10 | |
PKC-412 is a broad-spectrum kinase inhibitor that targets various signaling pathways, including those converging on Ang-1 regulation. By inhibiting specific kinases within these pathways, PKC-412 indirectly influences Ang-1 activity, disrupting the interconnected network of signaling events that govern its function. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective Src family kinase inhibitor. By targeting Src, a kinase implicated in Ang-1 phosphorylation, PP2 indirectly modulates Ang-1 activity. The disruption of Src-mediated signaling represents a specific point of intervention in the regulatory network governing Ang-1 function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that influences multiple signaling pathways, including those connected to Ang-1. By targeting kinases within these pathways, Genistein indirectly modulates Ang-1 activity, disrupting the signaling network and influencing downstream events regulated by Ang-1. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 inhibits JAK2, a kinase implicated in Ang-1 signaling. By targeting JAK2, Tyrphostin B42 indirectly modulates Ang-1 activity, disrupting the signaling network downstream of JAK2. This intervention at the level of JAK2 represents a specific strategy to influence Ang-1 function and related cellular processes. | ||||||