AMPKγ1 Activators
The chemical class termed AMPKγ1 Activators comprises a diverse array of compounds that indirectly influence the activity of the AMPKγ1 subunit of AMP-activated protein kinase. These compounds primarily function by modulating cellular energy status, mitochondrial function, and redox balance, leading to the activation of AMPK, including its γ1 subunit.
Compounds such as Metformin, AICAR, and Berberine are key examples in this class. They activate AMPK by altering the AMP/ATP ratio within the cell. Metformin and Berberine inhibit mitochondrial complex I, leading to increased AMP levels relative to ATP, which activates AMPK. AICAR mimics AMP and directly activates AMPK. These mechanisms ensure that when cellular energy levels are low, AMPK, including AMPKγ1, is activated to restore energy balance.,Other notable compounds like Resveratrol, Salicylate, and SRT1720 exert their effects through pathways related to deacetylation and antioxidant properties. Resveratrol and SRT1720 activate SIRT1, which in turn activates AMPK through the deacetylation of LKB1, a kinase upstream of AMPK. Salicylate activates AMPK by inhibiting deacetylase activity. Additionally, molecules such as Quercetin, EGCG, Curcumin, and Capsaicin activate AMPK through various mechanisms related to oxidative stress, lipid metabolism, and calcium.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMPK indirectly by inhibiting complex I of the mitochondrial respiratory chain, leading to an increase in AMP/ATP ratio and subsequent AMPK activation, including AMPKγ1. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator that mimics AMP. It activates AMPK by increasing the AMP/ATP ratio, thereby potentially influencing AMPKγ1 activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates AMPK by inhibiting mitochondrial function, similar to metformin, leading to an increased AMP/ATP ratio and activation of AMPK, including AMPKγ1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate AMPK indirectly through SIRT1 activation. SIRT1 activation leads to deacetylation of LKB1, a kinase that activates AMPK, including AMPKγ1. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylate activates AMPK by inhibiting deacetylase activity, which can indirectly affect AMPKγ1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can activate AMPK indirectly through its antioxidant properties, influencing the cellular redox state and potentially impacting AMPKγ1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, found in green tea, activates AMPK, potentially through its effects on cellular energy status, thus influencing AMPKγ1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates AMPK indirectly, possibly through modulation of lipid metabolism and influencing cellular energy balance, affecting AMPKγ1. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates AMPK through its effects on calcium signaling and cellular energy status, potentially impacting AMPKγ1. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid activates AMPK by influencing mitochondrial function and the cellular redox state, which can affect AMPKγ1. | ||||||