AMPKγ1 Inhibitors

AMPKγ1 Inhibitors, a class that encompasses compounds that, while not directly inhibiting AMPKγ1, exert their effects by modulating the broader AMPK pathway. AMPK, a key regulator of cellular energy homeostasis, is a heterotrimeric complex consisting of α, β, and γ subunits, with γ1 being one of the isoforms of the regulatory γ subunit. The indirect inhibitors listed here primarily function by altering the kinase activity of the AMPK complex, thereby influencing the regulatory role of AMPKγ1.

The mechanisms through which these compounds modulate AMPK activity are diverse. Some, like Compound C and Dorsomorphin, are known to inhibit the kinase activity of AMPK, thus indirectly affecting the function of AMPKγ1 within the complex. Others, such as A-769662 and MK-8722, target specific isoforms or activate the entire AMPK complex, thereby influencing AMPKγ1's regulatory role. Importantly, these compounds highlight the intricate interplay within the AMPK complex and demonstrate how modulation of one subunit or the overall kinase activity can impact the function of AMPKγ1.