α-taxilin Inhibitors
The chemical class broadly defined as α-taxilin inhibitors encompasses a diverse group of compounds that indirectly modulate the biological activity of the α-taxilin protein. The inhibition is not direct but occurs through the interruption or alteration of various cellular signaling pathways and processes that α-taxilin is known to influence, particularly those involved in vesicle formation, trafficking, and cellular transport mechanisms. These chemicals typically have primary targets other than α-taxilin but have been observed to impact cellular functions that are consistent with the roles α-taxilin plays in the cell.
The inhibitors listed are characterized by their actions on different cellular targets such as phosphoinositide 3-kinases (PI3Ks), Golgi apparatus disruption, microtubule dynamics, dynamins, tyrosine kinases, and ROCK (Rho-associated protein kinase). By altering the activity of these proteins and enzymes, the chemicals exert an indirect effect on vesicle trafficking, transport systems, and the actin cytoskeleton. Consequently, these inhibitors affect the cellular processes and signaling pathways that are relevant to the functional activity of α-taxilin. Despite the disparate chemical structures and primary mechanisms of action, these compounds are unified by their collective ability to influence α-taxilin's role in the cell indirectly.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3K, a kinase involved in the signaling pathway affecting vesicle trafficking where α-taxilin functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A specific inhibitor of PI3K, leading to downstream effects on cellular trafficking. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Disrupts Golgi function and can impact vesicle transport processes associated with α-taxilin. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Inhibits ADP-ribosylation factor, altering Golgi and ER function and potentially affecting α-taxilin's role in trafficking. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Inhibitor of dynamin which is crucial for vesicle scission, a step necessary for vesicle trafficking involving α-taxilin. | ||||||
Dynamin Inhibitor II | 1119-97-7 | sc-203931 sc-203931A sc-203931B sc-203931C | 5 g 250 g 500 g 1 kg | $47.00 $84.00 $124.00 $198.00 | ||
Blocks dynamin's interaction with lipid membranes, thereby disrupting processes linked to α-taxilin. | ||||||
Dynole 34-2 | 1128165-88-7 | sc-362731 sc-362731A | 10 mg 50 mg | $205.00 $849.00 | ||
Dynamin GTPase inhibitor, affecting vesicle formation and trafficking. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules, affecting cellular transport systems where α-taxilin is involved. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules, altering dynamics of microtubule-based transport, indirectly affecting α-taxilin. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Tyrosine kinase inhibitor, which may impact pathways related to α-taxilin's role in trafficking. | ||||||