Molecular structure of Dynole 34-2, CAS Number: 1128165-88-7
Dynole 34-2 (CAS 1128165-88-7)
Alternate Names:
2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Application:
Dynole 34-2 is an inhibitor of Dynamin I
CAS Number:
1128165-88-7
Purity:
≥98%
Molecular Weight:
408.58
Molecular Formula:
C25H36N4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dynole 34-2, an organic compound. This cyclic diamide emerges through the synthesis of diverse organic precursors and has found extensive application in numerous scientific investigations exploring the impact of various compounds. Although the full extent of its mechanism of action remains elusive, it is hypothesized that Dynole 34-2 exerts its influence through binding to specific proteins, thereby activating signaling pathways.
Dynole 34-2 (CAS 1128165-88-7) References
- Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. | Hill, TA., et al. 2009. J Med Chem. 52: 3762-73. PMID: 19459681
- Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. | Chircop, M., et al. 2011. Mol Cancer Ther. 10: 1553-62. PMID: 21750222
- Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPase. | Robertson, MJ., et al. 2014. Nat Protoc. 9: 851-70. PMID: 24651498
- Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release. | Jackson, J., et al. 2015. Mol Psychiatry. 20: 810-9. PMID: 25939402
- Time-dependent uptake and trafficking of vesicles capturing extracellular S100B in cultured rat astrocytes. | Lasič, E., et al. 2016. J Neurochem. 139: 309-323. PMID: 27488079
- Dynamin regulates the fusion pore of endo- and exocytotic vesicles as revealed by membrane capacitance measurements. | Lasič, E., et al. 2017. Biochim Biophys Acta Gen Subj. 1861: 2293-2303. PMID: 28669852
- Inhibition of endocytosis suppresses the nitric oxide-dependent release of Cl- in retinal amacrine cells. | Dunn, VK. and Gleason, E. 2018. PLoS One. 13: e0201184. PMID: 30044876
- Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis. | Khan, I., et al. 2019. Cancer Res. 79: 4689-4702. PMID: 31311812
- Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells. | Tremblay, CS., et al. 2020. Nat Commun. 11: 6211. PMID: 33277497
- Asymmetric distribution of dynamin-2 and β-catenin relative to tight junction spikes in alveolar epithelial cells. | Lynn, KS., et al. 2021. Tissue Barriers. 9: 1929786. PMID: 34107845
- Dynamin Inhibitors Prevent the Establishment of the Cytomegalovirus Assembly Compartment in the Early Phase of Infection. | Štimac, I., et al. 2021. Life (Basel). 11: PMID: 34575026
- Dynole 34-2 and Acrylo-Dyn 2-30, Novel Dynamin GTPase Chemical Biology Probes. | Baker, JR., et al. 2022. Methods Mol Biol. 2417: 221-238. PMID: 35099803
- Triazole-derivatized near-infrared cyanine dyes enable local functional fluorescent imaging of ocular inflammation. | Thomas, CN., et al. 2022. Biosens Bioelectron. 216: 114623. PMID: 36029662
Inhibitor of:
α-taxilin, Clathrin HC, Dynamin I, Dynamin II, Dynamin III, Enzyme, FCHO1, Intersectin, and Intersectin-2.Activator of:
Endophilin III.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dynole 34-2, 10 mg | sc-362731 | 10 mg | $205.00 | |||
| US: Only available in the US | ||||||
Dynole 34-2, 50 mg | sc-362731A | 50 mg | $849.00 | |||
| US: Only available in the US | ||||||