ALP Inhibitors
The diverse array of chemicals identified as ALP inhibitors reveals a nuanced approach to modulating the activity of alkaline phosphatase. Among these, Okadaic Acid and Fostriecin stand out as indirect inhibitors, targeting protein phosphatases (PP2A) and disrupting the delicate balance of ALP dephosphorylation. Their interference with the regulatory machinery illustrates the intricate control governing ALP activity, where perturbations in phosphatase activity can lead to sustained phosphorylation and subsequent inhibition of ALP. Cantharidin and Norcantharidin, by virtue of disrupting protein phosphatases (PP1 and PP2A), present another avenue for ALP inhibition. These compounds showcase the importance of precise phosphatase regulation in maintaining ALP activity, and their interference results in sustained phosphorylation and subsequent inhibition.
Cyclosporin A takes a different approach by targeting calcineurin, a calcium-dependent phosphatase that modulates ALP activity. Through inhibition of calcineurin, Cyclosporin A disrupts the dephosphorylation of ALP, providing an alternate angle for ALP inhibition. Additionally, several compounds such as GW5074, BCI, Nsc-87877, and Indirubin intervene in the ERK signaling pathway, influencing the phosphorylation cascade that regulates ALP. Their role as ERK inhibitors showcases the interconnectedness of signaling pathways in governing ALP activity. Furthermore, Niclosamide acts indirectly by targeting the Wnt/β-catenin signaling pathway, suggesting that modulation of this pathway can influence ALP activity. This highlights the crosstalk between ALP and critical cellular signaling pathways. In summary, the chemical class of ALP inhibitors encompasses a range of compounds that act through diverse mechanisms, including interference with protein phosphatases, modulation of signaling pathways, and disruption of cellular dynamics. These findings deepen our understanding of the intricate regulatory networks governing ALP activity and provide valuable insights for future investigations into targeted interventions for this enzyme.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits ALP indirectly by blocking protein phosphatase 2A (PP2A), a critical phosphatase that regulates ALP dephosphorylation. Inhibition of PP2A disrupts the dephosphorylation balance, leading to the hyperphosphorylation of ALP and subsequent inhibition of its activity. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin acts as an indirect ALP inhibitor by disrupting protein phosphatase 1 (PP1) and PP2A activity. Through its interaction with PP1 and PP2A, cantharidin impedes the dephosphorylation of ALP, resulting in its sustained phosphorylation and inhibition. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $260.00 | 9 | |
Fostriecin inhibits ALP indirectly by specifically targeting protein phosphatase 2A (PP2A). By interfering with PP2A activity, fostriecin disrupts the balance of ALP phosphorylation, leading to ALP inhibition. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A acts as an indirect ALP inhibitor by interfering with calcineurin, a calcium-dependent phosphatase that regulates ALP activity. Inhibition of calcineurin disrupts the dephosphorylation of ALP, resulting in its inhibition. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 inhibits ALP by targeting the ERK signaling pathway. As an inhibitor of MEK, an upstream kinase in the ERK pathway, GW5074 disrupts the phosphorylation cascade that regulates ALP activity, leading to its inhibition. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Niclosamide acts as an indirect ALP inhibitor by targeting the Wnt/β-catenin signaling pathway. Through its impact on Wnt signaling, niclosamide modulates the phosphorylation status of ALP, leading to its inhibition. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $112.00 $515.00 | 4 | |
Indirubin inhibits ALP by targeting cyclin-dependent kinases (CDKs). As a CDK inhibitor, indirubin disrupts the phosphorylation events that regulate ALP activity, resulting in its inhibition. | ||||||
NSC 87877 | 56990-57-9 | sc-204139 | 50 mg | $134.00 | 12 | |
NSC-87877 inhibits ALP indirectly by targeting the ERK signaling pathway. As an ERK inhibitor, NSC-87877 disrupts the phosphorylation cascade that regulates ALP activity, leading to its inhibition. | ||||||
Norcantharidin | 29745-04-8 | sc-280719 | 5 g | $111.00 | 2 | |
Norcantharidin acts as an indirect ALP inhibitor by disrupting protein phosphatase 1 (PP1) and PP2A activity. Through its interaction with PP1 and PP2A, norcantharidin impedes the dephosphorylation of ALP, resulting in its sustained phosphorylation and inhibition. | ||||||