ALG-4 Activators
indirectly stimulate the functional activation of ALG-4 through specific signaling pathways. Epinephrine, Forskolin, and Isoproterenol, for instance, activate adenylyl cyclase which leads to an increase in cAMP levels. This elevation in cAMP then triggers PKA, which can phosphorylate and activate ALG-4. This series of events showcases how these chemicals directly influence the functional activity of ALG-4. In contrast, Phorbol 12-Myristate 13-Acetate (PMA) operates through a different mechanism, activating protein kinase C (PKC) which can then phosphorylate and stimulate ALG-4.
Other ALG-4 Activators, such as Okadaic Acid and Calyculin A, operate by inhibiting deactivating enzymes, leading to sustained activation of ALG-4. These chemicals inhibit protein phosphatases 1 and 2A, enzymes responsible for the dephosphorylation and consequent deactivation of ALG-4. By obstructing these enzymes, Okadaic Acid and Calyculin A prevent the deactivation of ALG-4, leading to its continued activation. Similarly, H-89 and Staurosporine inhibit protein kinases, resulting in the upregulation of cAMP levels and indirect activation ofALG-4. H-89 inhibits PKA, leading to the upregulation of cAMP levels, while Staurosporine inhibits PKC, altering cellular signaling pathways and indirectly leading to the activation of ALG-4.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates adrenergic receptors, leading to an increase in cyclic AMP levels. The elevated cAMP activates PKA, which can phosphorylate and activate ALG-4. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP levels. The elevated cAMP activates PKA, which can subsequently activate ALG-4. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol activates β-adrenergic receptors, leading to an increase in cAMP levels. The elevated cAMP activates PKA, which can in turn activate ALG-4. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC). PKC activation can lead to phosphorylation and activation of ALG-4. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid inhibits protein phosphatases 1 and 2A. By inhibiting these phosphatases, Okadaic Acid prevents dephosphorylation, allowing for sustained activation of ALG-4. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A. By inhibiting these phosphatases, Calyculin A can lead to sustained activation of ALG-4. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to phosphorylation and activation of ALG-4. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a potent and selective inhibitor of PKA. In the presence of cAMP, PKA can activate ALG-4. Thus, the inhibition of PKA with H-89 can lead to the upregulation of cAMP levels, indirectly leading to the activation of ALG-4. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC. Inhibition of PKC can lead to altered cellular signaling pathways, indirectly leading to the activation of ALG-4. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. By inhibiting phosphodiesterases, IBMX can increase cAMP levels, leading to the activation of PKA and subsequently ALG-4. | ||||||