AI464131 Activators
Chemical activators of the myogenesis regulating glycosidase (putative) can employ a variety of mechanisms to enhance its activity. Forskolin directly stimulates adenylate cyclase, which catalyzes the conversion of ATP to cyclic AMP (cAMP). The rise in cAMP levels results in the activation of protein kinase A (PKA), a kinase that plays a crucial role in phosphorylating proteins that may interact with or directly modify the myogenesis regulating glycosidase (putative), promoting its enzymatic function. Similarly, IBMX elevates intracellular cAMP concentrations by inhibiting phosphodiesterases that degrade cAMP, which also leads to PKA activation and subsequent phosphorylation of proteins associated with the glycosidase. Piceatannol disrupts the action of Syk kinases, altering the phosphorylation states of proteins that modulate the glycosidase's activity, while sodium fluoride acts by inhibiting phosphatases, thereby maintaining a higher level of phosphorylation within the cell, which can indirectly facilitate the glycosidase's activity.
Further activation mechanisms involve okadaic acid and cantharidin, both inhibitors of protein phosphatases PP1 and PP2A. The inhibition of these phosphatases prevents the dephosphorylation of proteins, ensuring that the phosphorylation state remains high, which can lead to activation of the myogenesis regulating glycosidase (putative). Anisomycin activates stress-activated protein kinases (SAPKs), which may phosphorylate and activate proteins associated with the glycosidase. A23187, by increasing intracellular calcium levels, can activate calcium-dependent protein kinases that potentially phosphorylate the glycosidase or its associated proteins. Phorbol 12-myristate 13-acetate (PMA) stimulates protein kinase C (PKC), which is known to phosphorylate a wide array of proteins, possibly including those interacting with the glycosidase. Retinoic acid modulates gene expression and might activate signaling pathways that lead to the activation of the glycosidase. Lastly, zinc chloride and manganese (II) chloride can enhance the glycosidase's activity by serving as cofactors that stabilize the enzyme's structure or by activating kinases that phosphorylate proteins which regulate the activity of the glycosidase.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP enhances protein kinase A (PKA) activity, which can activate the myogenesis regulating glycosidase (putative) by phosphorylating proteins that interact with or modify the activity of the glycosidase, thereby promoting its enzymatic function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which increases intracellular cAMP by preventing its breakdown. Enhanced cAMP levels lead to activation of PKA. Active PKA can then phosphorylate proteins associated with myogenesis regulating glycosidase (putative), leading to an increase in its functional activity. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol inhibits the Syk kinase, which may lead to altered phosphorylation states of downstream proteins that regulate the activity of the myogenesis regulating glycosidase (putative). By changing the phosphorylation patterns, piceatannol can enhance the glycosidase's activity through a cascade of intracellular signaling events. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride is an activator of various enzymes through its inhibitory effect on phosphatases, leading to increased phosphorylation levels within the cell. This can result in enhanced activity of enzymes such as the myogenesis regulating glycosidase (putative) by maintaining or promoting the phosphorylation of proteins that regulate its activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased protein phosphorylation. This amplifies the activity of kinases and can result in the activation of myogenesis regulating glycosidase (putative) by phosphorylation of proteins in its proximity or that regulate its activity directly or indirectly. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin is another inhibitor of protein phosphatases like PP1 and PP2A, which can lead to increased phosphorylation within the cell. This may facilitate the activation of the myogenesis regulating glycosidase (putative) via enhanced phosphorylation of proteins that influence the glycosidase's activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can lead to the activation of stress-activated protein kinases (SAPKs). Activated SAPKs can phosphorylate various cellular proteins, potentially including those associated with the myogenesis regulating glycosidase (putative), thereby enhancing its activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent protein kinases, which may then phosphorylate and activate the myogenesis regulating glycosidase (putative) by altering the phosphorylation status of the glycosidase itself or proteins that modulate its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in a wide range of cellular signaling pathways. Activated PKC can phosphorylate and activate proteins that may interact with the myogenesis regulating glycosidase (putative), leading to its functional activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can influence cellular differentiation processes and may activate signaling pathways that lead to the post-translational modification and activation of proteins, including myogenesis regulating glycosidase (putative). | ||||||