AI314180 Activators
AI314180 Activators comprise a diverse array of chemicals that influence specific adrenergic and protein kinase signaling pathways that AI314180 is directly involved in. Epinephrine, Forskolin, and Isoproterenol, all activators of adenylyl cyclase through adrenergic receptors or directly, lead to an increase in cAMP levels. The elevated cAMP activates PKA, which can in turn activate AI314180. Furthermore, Phorbol 12-Myristate 13-Acetate (PMA) directly activates protein kinase C (PKC), leading to the activation of AI314180.
Other AI314180 activators work indirectly by inhibiting enzymes that would typically reduce AI314180 activity. Okadaic Acid and Calyculin A inhibit protein phosphatases 1 and 2A, preventing the dephosphorylation of AI314180 and thus leading to its sustained activation. Similarly, H-89 and Staurosporine inhibit protein kinases, and this inhibition can, in a feedback loop mechanism, lead to the upregulation of cAMP levels, indirectly activating AI314180. Lastly, IBMX, Rolipram, and SQ22536 increase cAMP levels by inhibiting phosphodiesterases or adenylyl cyclase, respectively, and these raised cAMP levels can subsequently activate PKA and AI314180.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is a catecholamine that can activate adrenergic receptors. This activation leads to an increase in cyclic AMP levels and activation of protein kinase A (PKA), which can phosphorylate and activate AI314180. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene that can activate adenylyl cyclase, leading to an increase in cyclic AMP levels. The elevated cAMP activates PKA, which can in turn activate AI314180. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates β-adrenergic receptors, leading to an increase in cAMP levels. The elevated cAMP activates PKA, which can subsequently activate AI314180. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to phosphorylation and activation of AI314180. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A. Inhibition of these phosphatases prevents dephosphorylation, allowing for sustained activation of AI314180. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, Calyculin A can lead to sustained activation of AI314180. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to phosphorylation and activation of AI314180. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is a potent and selective inhibitor of PKA. In the presence of cAMP, PKA can activate AI314180. Thus, in a feedback loop mechanism, the inhibition of PKA with H-89 can lead to the upregulation of cAMP levels, indirectly leading to the activation of AI314180. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC. Inhibition of PKC can lead to altered cellular signaling pathways, indirectly leading to the activation of AI314180. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. By inhibiting phosphodiesterases, IBMX can increase cAMP levels, leading to the activation of PKA and subsequently AI314180. | ||||||