AGAT Activators
AGAT activators refer to a class of chemical compounds that hold significant importance in the realm of biochemistry and physiological research. AGAT, or Arginine:Glycine Amidinotransferase, is an enzyme primarily involved in the biosynthesis of creatine, a crucial molecule for energy storage and transfer in various tissues, especially in muscles and the brain. Activators of AGAT are molecules that enhance the activity of this enzyme, ultimately facilitating the conversion of arginine and glycine into guanidinoacetate, a key precursor in the creatine synthesis pathway.
These AGAT activators operate through diverse mechanisms, such as direct binding to the enzyme or influencing the enzymatic environment. By increasing AGAT's activity, these compounds promote the efficient production of guanidinoacetate, which is subsequently transformed into creatine, aiding in the maintenance of cellular energy homeostasis. This class of compounds is of significant interest to scientists and researchers studying the intricacies of cellular metabolism, as understanding their modes of action can shed light on the broader regulatory mechanisms within the body. AGAT activators have the potential to be valuable tools for elucidating the nuances of creatine biosynthesis and its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $27.00 $77.00 | 2 | |
Creatine directly activates AGAT by serving as a substrate in the creatine synthesis pathway, stimulating AGAT to convert glycine and arginine into guanidinoacetate. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $40.00 $70.00 $110.00 $350.00 | 15 | |
Glycine activates AGAT by acting as one of its substrates, participating in the conversion of glycine and arginine into guanidinoacetate. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
Arginine is another substrate that activates AGAT by participating in the synthesis of guanidinoacetate, a key step in creatine production. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
SAM indirectly activates AGAT by donating a methyl group, promoting the methylation of guanidinoacetate, which enhances creatine biosynthesis. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
Methionine indirectly activates AGAT by providing the sulfur atoms needed for the synthesis of SAM, which supports creatine production. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $102.00 | ||
Pyridoxal 5'-phosphate serves as a cofactor in the AGAT reaction, indirectly activating the enzyme by facilitating the conversion of glycine and arginine into guanidinoacetate. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic acid indirectly activates AGAT by participating in one-carbon metabolism, supporting the production of SAM, which aids in creatine synthesis. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $39.00 $55.00 $204.00 $877.00 $3414.00 $9180.00 | 2 | |
Vitamin B12 indirectly activates AGAT by being essential for one-carbon metabolism, which is critical for SAM production and creatine biosynthesis. | ||||||
L-Methionine [R,S]-Sulfoximine | 15985-39-4 | sc-207806 | 1 g | $388.00 | ||
This compound indirectly activates AGAT by inhibiting the enzyme GABA-T, which reduces the degradation of glycine and increases its availability for guanidinoacetate production. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine activates AGAT by promoting the synthesis of S-adenosylmethionine (SAM), a methyl donor that supports the methylation of guanidinoacetate. | ||||||