ADO Activators
The chemicals listed primarily influence the metabolism and cellular levels of 2'-deoxyadenosine (ADO) rather than directly activating it. ADO metabolism is integral to nucleic acid metabolism and is closely related to cellular processes such as DNA synthesis and repair. The compounds include various inhibitors of enzymes involved in ADO metabolism, such as adenosine kinase and adenosine deaminase, as well as nucleoside analogs used in chemotherapy that can affect ADO levels indirectly by interfering with DNA synthesis and repair mechanisms. For instance, adenosine kinase inhibitors can lead to increased ADO levels by reducing its phosphorylation, while inhibitors of adenosine deaminase like deoxycoformycin (Pentostatin) prevent the deamination of ADO, leading to its accumulation.
Additionally, ribavirin and zidovudine (AZT) can also impact nucleoside metabolism. They can alter the balance of nucleoside and nucleotide pools in the cell, which can indirectly affect ADO levels and metabolism. Understanding these influencers of ADO is important in contexts such as the study of nucleoside metabolism disorders. Manipulating ADO levels through these chemicals can have significant implications for the understanding of cellular metabolism.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pentostatin | 53910-25-1 | sc-204177 sc-204177A | 10 mg 50 mg | $172.00 $702.00 | 5 | |
An inhibitor of adenosine deaminase, which can increase ADO levels by preventing its deamination. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
As an antifolate drug, it can influence purine metabolism, potentially affecting ADO levels indirectly. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
An antiviral drug that can influence nucleoside metabolism and potentially impact ADO levels. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
A chemotherapy agent in research that is a purine analog, which can interfere with DNA synthesis and potentially impact ADO metabolism. | ||||||
2-Chloro-2′-deoxyadenosine | 4291-63-8 | sc-202399 | 10 mg | $144.00 | 1 | |
Another purine analog used in chemotherapy, which can affect ADO metabolism. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Used in cancer treatment, it can influence DNA synthesis and repair, thereby potentially affecting ADO levels. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
A agent in research used to treat cancer, it can interfere with DNA synthesis, potentially impacting the metabolism of nucleosides including ADO. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
A nucleoside analog used in chemotherapy, which can interfere with DNA replication, potentially affecting ADO metabolism. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $48.00 $72.00 $265.00 $449.00 $1724.00 $112.00 | 16 | |
As a pyrimidine nucleoside, thymidine supplementation can affect the overall balance of nucleoside metabolism, including that of ADO. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $147.00 $258.00 $508.00 $717.00 $1432.00 | 1 | |
A chemotherapy drug, a cytidine analog that can impact nucleoside metabolism, potentially affecting ADO levels. | ||||||