ADM Receptor Activators
ADM Receptor Activators comprise chemical compounds that influence the ADM receptor by increasing intracellular cAMP levels, which leads to protein kinase A activation. This activation triggers phosphorylation of the ADM receptor, enhancing its function. Notably, these activators can be classified into several categories, including catecholamines (e.g., norepinephrine, epinephrine, isoproterenol, and dopamine), phosphodiesterase inhibitors (e.g., sildenafil, theophylline, caffeine, and rolipram), and compounds that directly or indirectly increase cAMP levels (e.g., forskolin, dibutyryl-cAMP, adenosine, and adenine).
These compounds contribute to the functional activation of the ADM receptor in a few distinct but interconnected ways. Catecholamines and adenosine interact with their respective receptors, leading to an increase in adenylyl cyclase activity and subsequently, cAMP production. Phosphodiesterase inhibitors prevent the breakdown of cAMP, maintaining high intracellular cAMP levels. Forskolin directly stimulates adenylyl cyclase activity, while dibutyryl-cAMP, a cell-permeable cAMP analogue, bypasses this step, directly activating protein kinase A. Collectively, these ADM receptor activators contribute to the phosphorylation and functional activation of the ADM receptor by leveraging the cAMP-protein kinase A signaling pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine, a catecholamine, interacts with adrenergic receptors leading to an increase in intracellular cAMP levels. Elevated cAMP can activate protein kinase A, which phosphorylates the ADM receptor, thereby enhancing its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels. This triggers protein kinase A activation, which can phosphorylate and enhance the functional activity of the ADM receptor. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is a hormone and neurotransmitter that can bind to adrenergic receptors, increasing intracellular cAMP levels. This can lead to protein kinase A activation, which phosphorylates the ADM receptor, enhancing its function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that binds to beta-adrenergic receptors, increasing intracellular cAMP. Increased cAMP activates protein kinase A, which phosphorylates the ADM Receptor, enhancing its function. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analogue. It activates protein kinase A, which can phosphorylate and enhance ADM receptor activation. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline is a non-selective phosphodiesterase inhibitor, which can increase cAMP level. Elevated cAMP activates protein kinase A, which phosphorylates the ADM receptor, enhancing its function. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine activates adenylyl cyclase, leading to increased cAMP levels. The elevated cAMP activates protein kinase A, which phosphorylates and enhances the functional activity of the ADM receptor. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits the action of phosphodiesterase, leading to increased cAMP levels, which can amplify protein kinase A activity. Protein kinase A can phosphorylate the ADM receptor, enhancing its functional activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 inhibitor. It increases cAMP levels, activating protein kinase A, which phosphorylates and activates the ADM receptor. | ||||||
Adenine, cell culture grade | 73-24-5 | sc-291834 sc-291834A sc-291834B | 5 g 25 g 100 g | $82.00 $206.00 $546.00 | 2 | |
Adenine forms the basis of adenosine, which increases cAMP levels. Elevated cAMP activates protein kinase A, which phosphorylates and enhances the functional activity of the ADM receptor. | ||||||