ADAT1 Inhibitors
The ADAT1 Inhibitors principally target broader cellular processes and pathways that revolve around tRNA, its modification, and the general machinery of protein translation. While the direct inhibition of ADAT1 remains elusive, targeting processes adjacent to ADAT1's function may present opportunities to indirectly modulate its activity.
Halofuginone and Mimosine, for instance, are inhibitors of aminoacyl-tRNA synthetases. By affecting tRNA aminoacylation, there's the to indirectly impact tRNA modifications done by enzymes like ADAT1. Compounds like Cordycepin and Ribavirin, being analogues of nucleosides, have the to influence pathways related to tRNA modifications. Their incorporation into RNA might affect the substrate availability or recognition by enzymes like ADAT1. The intricate balance in the protein translation machinery, encompassing enzymes responsible for tRNA modifications, suggests that perturbations in this equilibrium can have cascading effects. Puromycin and Cycloheximide, known to disrupt protein translation, could indirectly affect tRNA modification enzymes as changes in the translation process might change the demand for specific tRNA modifications.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1740.00 | ||
An inhibitor of prolyl-tRNA synthetase, potentially affecting tRNA aminoacylation and indirectly affecting tRNA modifications like those done by ADAT1. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
Adenosine analogue that can affect various adenosine-related pathways. Its potential to disrupt ADAT1's substrate recognition remains to be fully elucidated. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
A guanosine analogue which can impact various RNA processes, and potentially affect tRNA modification enzymes indirectly. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Affects RNA processing, which may indirectly influence tRNA modification enzymes like ADAT1. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
As the substrate for ADAT1, high concentrations of adenosine might saturate the enzyme and indirectly reduce its activity. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $102.00 $408.00 $642.00 $1275.00 | 10 | |
An inhibitor of several enzymes that use glutamine as a substrate. Its broader effect on protein translation might indirectly influence ADAT1. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
An antibiotic that disrupts protein translation by acting as a tRNA analogue. Might indirectly affect tRNA modification enzymes. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Blocks eukaryotic translation, which might indirectly affect the demand for tRNA modification. | ||||||
Brassinin | 105748-59-2 | sc-202978 sc-202978A sc-202978B sc-202978C | 50 mg 100 mg 250 mg 1 g | $240.00 $381.00 $900.00 $2700.00 | 2 | |
Known to inhibit indoleamine-2,3-dioxygenase. While not directly linked to ADAT1, it's involved in tryptophan metabolism and can influence various cell processes. | ||||||
Difluoromethylornithine | 70052-12-9 | sc-204723 sc-204723A sc-204723B sc-204723C sc-204723D sc-204723E | 10 mg 25 mg 100 mg 250 mg 1 g 5 g | $58.00 $130.00 $158.00 $311.00 $964.00 $4726.00 | 2 | |
Ornithine decarboxylase inhibitor. By affecting polyamine synthesis, it can influence RNA stability and potentially tRNA modification. | ||||||