ADAMTS-2 Activators
A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) represents a family of enzymes known for their role in extracellular matrix (ECM) remodeling and degradation. Within this family, ADAMTS-2 stands out for its specificity in cleaving procollagen to facilitate the formation of mature collagen fibers. It is an intricate protein comprising multiple domains, including a metalloproteinase domain, a disintegrin-like domain, and thrombospondin motifs. This multi-domain structure enables it to interact with a wide range of biomolecules and makes it a critical player in the dynamic balance of the ECM. ADAMTS-2 activity is intricately regulated at multiple layers, encompassing transcriptional and translational modulation, post-translational modifications, and the interplay with natural inhibitors and cofactors. Factors like cytokines, growth factors, and mechanical stress can influence the expression and enzymatic activity of ADAMTS-2.
ADAMTS-2 Activators can either directly or indirectly enhance the activity or expression of ADAMTS-2. For instance, some small molecules can inhibit pathways that are antagonistic to ADAMTS-2 expression, serving as indirect activators. Another way to influence ADAMTS-2 is via epigenetic modulators, such as histone deacetylase (HDAC) inhibitors, which could enable increased gene expression. Substrate availability is another point of regulation; small molecules that stabilize the ECM may thereby enhance the substrate pool upon which ADAMTS-2 acts. Some activators might function by modulating the oxidative stress environment, affecting the optimal function of ADAMTS-2. These chemicals, therefore, function within a vast network of biological pathways to modulate the activity of ADAMTS-2, which in turn has a profound impact on ECM integrity and homeostasis.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
This TGF-β inhibitor could potentially upregulate ADAMTS-2 by suppressing signaling pathways known to downregulate ADAMTS expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
An HDAC inhibitor that could facilitate ADAMTS-2 gene expression through epigenetic modification. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Influences collagen synthesis, which may indirectly impact ADAMTS-2 activity by altering substrate availability in the ECM. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $75.00 $265.00 | 55 | |
An MMP inhibitor that could help maintain ECM substrates for ADAMTS-2, thus indirectly activating it. | ||||||
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $102.00 | ||
These could stabilize the ECM, affecting the substrate availability for ADAMTS-2. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
As a PDGF Small Molecule Inhibitor, it could affect ADAMTS-2 activity by interfering with growth factor-mediated ECM remodeling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
An Nrf2 activator that might influence ADAMTS-2, particularly under conditions of oxidative stress. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $82.00 $295.00 $367.00 $764.00 | 25 | |
A hydroxylase inhibitor that could affect post-translational modifications of ADAMTS-2, thereby potentially affecting its stability or activity. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
As a reactive oxygen species (ROS) scavenger, it could activate ADAMTS-2 by reducing oxidative stress that may impair its activity. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
A gamma-secretase inhibitor that interferes with Notch signaling and could indirectly influence ADAMTS-2 expression or activity. | ||||||